Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (4): 23-27.doi: 10.6040/j.issn.1671-7554.0.2018.032

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Mitochondrial defects and premature ovarian failure

TONG Chao   

  1. Life Sciences Institute, Zhejiang University, Hangzhou 310058, Zhejiang, China
  • Published:2022-09-27

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Abstract: Premature ovarian failure(POF)is a severe reproductive disease leading to infertility which affects many women. However, its etiology is not clear. Mitochondria, the energy factory and center of metabolism, participates many cellular activities. Malfunctions of mitochondria are associated with POF. Mitochondrion is the only organelle that has its own genome in the mammalian cells. In the majority of species, mitochondria are transmitted maternally, which means that oocyte is the only carrier that passes mitochondrial DNA(mtDNA)to the next generation. Oocytes are large and have many copies of mtDNA. The mitochondria in oocytes have distinct morphology compared with that in the 山 东 大 学 学 报 (医 学 版)56卷4期 -佟超.线粒体异常与卵巢早衰 \=-somatic cells. These special features of mitochondria in ovary lead to special regulatory mechanisms. In this review, we discussed how the defects in mtDNA, mitochondrial protein homeostasis, and mitochondrial dynamics lead to ovarian dysfunction.

Key words: Mitochondria, Premature ovarian failure, Mitochondrial DNA, Mitochondrial dynamics, Perrault syndrome

CLC Number: 

  • Q28
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