Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (8): 84-90.doi: 10.6040/j.issn.1671-7554.0.2021.1377

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Diarrhea as the principal presentation of Waldenström macroglobulinemia: a case report and literature review

AN Wen1, HUANG Gang1, YU Yanbo2, ZUO Xiuli2, LI Yanqing2   

  1. 1. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-07-27

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Abstract: Objective To enhance clinicians understanding of the involvement of gastrointestinal tract in Waldenström macroglobulinemia(WM). Methods A case of chronic diarrhea with weight loss diagnosed as WM was reported. Relevant literature was reviewed. Results The WM case was associated with significant gastrointestinal involvement, manifested as chronic diarrhea with weight loss and hypoproteinemia. Small bowel biopsy was negative for amyloidosis. Rituximab in combination with bendamustine soon relieved the diarrhea. Literature about the association of WM with gastrointestinal symptoms was reviewed. Conclusion An increased awareness of the gastrointestinal manifestations of WM may help to explain and treat the indolent, potentially life-threatening lymphatic malignancy.

Key words: Waldenströ, m macroglobulinemia, Diarrhea, Hypoproteinemia, Weight loss

CLC Number: 

  • R553
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