Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (8): 91-97.doi: 10.6040/j.issn.1671-7554.0.2022.0417

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A case report of hemophagocytic syndrome secondary to talaromyces marneffei infection

JIANG Ziqing1, ZENG Yanping1,2, JI Xiaodong2, ZUO Junling2   

  1. 1. The First Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    2. Emergency Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China
  • Published:2022-07-27

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Abstract: Objective To analyze the diagnosis and treatment of a patient with hemophagocytic syndrome(HPS)secondary to talaromyces marneffei(TM)infection, in order to improve clinicians understanding of the disease. Methods Clinical and laboratory data of a patient with TM infection secondary to HPS treated in our hospital were collected and analyzed, and relevant literature was reviewed. Results The patient, a 53-year-old man, with no history of malignant tumor or immune deficiency, presented with persistent fever, cough, expectoration, rashes, jaundice, hepatomegaly, splenomegaly, liver function impairment, decrease of hemoglobin and platelets, and increase of inflammation indicators, triglycerides and ferritin. TM was detected with sputum culture and metagenomic next-generation sequencing of peripheral blood. Macrophages were observed with bone marrow smear. After HPS secondary to TM infection was confirmed, the patient was treated with voriconazole and human immunoglobulin combined with glucocorticoid. Conclusion The clinical manifestations of TM infection are non-specific and the disease is difficult to diagnose. HPS secondary to TM infection increases the difficulty of treatment. Treatment should be tailored according to the condition of patients.

Key words: Talaromyces marneffei, Hemophagocytic syndrome, Diagnosis and treatment

CLC Number: 

  • R453
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