Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (12): 33-41.doi: 10.6040/j.issn.1671-7554.0.2021.0890

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Residue characteristics and health risk of beta-agonists in fodder-faeces-drinking water in intensive animal breeding area

XIA Huiyu1, LIU Zhong2, LIU Shumin3, LI Xuewen1   

  1. 1.Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Physical and Chemical Laboratory, Jinan Center for Disease Control and Prevention, Jinan 250021, Shandong, China;
    3. Animal Husbandry and Veterinary Station, Zhangxia Town, Changqing District, Jinan 250308, Shandong, China
  • Published:2021-12-29

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Abstract: Objective To investigate the residual characteristics of beta-agonists in fodder and faeces in an animal breeding area in eastern China, and to evaluate the human health risk of them in drinking water. Methods High performance liquid chromatography-mass spectrometry(HPLC-MS)was used to detect 12 beta-agonists in fodder(n=70), faeces(n=75)and drinking water(n=59)samples of different farms. Differences among faeces of different animal species were analyzed by Kruskal-Wallis test, and the health risks were evaluated by allowable daily intake(ADI). Results Beta-agonists were detected in all kinds of samples. The detection rate of 12 beta-agonists in fodder was higher than 50%. Detection rate of brombuterol was as high as 100%, and the concentration of fenoterol was the highest(102.94 μg/kg). Detection rate of beta-agonists in faeces was higher than 80%, and the detection rates of brombuterol and bromocreentrol were 100%; fenoterol was predominated(395.84 μg/kg)in faeces samples. The concentrations of beta-agonists in faeces of different livestock and poultry were statistical significant. Except terbutaline, the residual levels of other 11 substances in faeces were the highest in cattle farms(P<0.05). All beta-agonists were also detected in drinking water, and the detection rate of them was mostly more than 80%, of which brombuterol reached 100%, and the median concentration of fenoterol was the highest(30.09 ng/L). Through drinking water exposure, the non-carcinogenic health risk to human body of clenbuterol and ractopamine was relatively low. Conclusion A variety of beta-agonists were detected in the animal fodder and animal faeces in this study area. Beta-agonists in animal faeces can cause drinking water pollution through environmental diffusion. Thus, beta-agonists administrated in fodder needs to be paid great attention by local government.

Key words: Livestock and poultry, Intensive breeding, Beta-agonists, Drinking water, Health risk

CLC Number: 

  • R127
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