JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (9): 100-104.doi: 10.6040/j.issn.1671-7554.0.2017.123

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Influence of abortion and family heredity history on the risk of uterine leiomyomas

GONG Zhuo, ZHANG Minmin, WANG Zhiping   

  1. Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China
  • Received:2017-02-09 Online:2017-09-10 Published:2017-09-10

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Abstract: Objective To explore the influence of abortion and family heredity history on the risk of uterine leiomyomas, and to provide suggestions for preventing uterine leiomyomas. Methods A case-control study was undertook in this study. A structural questionnaire survey was used collecting the information of abortion experience, family history of uterine leiomyomas, age, height and other information among 20-65 years old married women from 10 urban and rural areas in Shandong province, China. The relations between both abortion experience, family history of uterine leiomyomas and uterine leiomyomas were analyzed by using Logistic regression model. Relative excess risk of interaction, attributable proportion of interaction and synergy index were used evaluating the interaction of abortion and family history of uterine leiomyomas. Results Results from multivariate unconditional Logistic regression model showed that abortion(OR=1.39, 95%CI: 1.06-1.80)and family heredity history of uterine leiomyomas(OR=2.07, 95%CI: 1.36-3.15)were risk factors of uterine leiomyomas. There was an addictive interaction of abortion and family heredity history on the risk of uterine leiomyomas (S=5.51, AP=0.59, RERI=2.14). Patients who had family heredity history and who had one or two more abortion increased the risk of uterine leiomyomas by 1.78 times and 2.77 times respectively. Conclusion Women who have family heredity history of uterine leiomyomas should pay attention to the pregnant plan and prevent abortion in order to reduce the risk of uterine leiomyomas.

Key words: Abortion, Interaction, Case-control study, Uterine Leiomyomas, Family heredity history, Logistic regression analysis

CLC Number: 

  • R181.2+3
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