JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (5): 62-65.doi: 10.6040/j.issn.1671-7554.0.2015.839

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Effects of prednisone therapy on the clinical outcomes and phenotypes of natural killer cells in patients with URSA

JIA Xinzhuan1, ZHANG Na1, GUO Lina1, ZHAO Suying1, DONG Cui1, WEI Lan2   

  1. 1. Department of Reproductive Medicine, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China;
    2. Department of Thoracic Surgery, Hebei Provincial Chest Hospital, Shijiazhuang 050041, Hebei, China
  • Received:2015-09-05 Online:2016-05-16 Published:2016-05-16

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Abstract: Objective To analyze the clinical outcomes(ongoing pregnancy > 12 weeks)and changes of natural killer(NK)cells CD56 and CD16 before and after prednisone treatment in patients with URSA(unexplained recurrent spontaneous abortion, URSA). Methods A total of 160 URSA patients were divided into two groups: experimental group(receiving prednisone and aspirin therapy, n=80), and control group(receiving placebo and aspirin therapy, n=80). The therapy started from 4-5 weeks to 12 weeks of gestation, and stopped if abortion occurred. The percentages of CD56 and CD16 were measured by flow cytometry before and after treatment. Results The percentage of ongoing pregnancy > 12 weeks was significantly higher in the experimental group than in the control group(P=0.00). The level of CD16 markedly dropped after treatment in the experimental group(P=0.00), while it remained unchanged in the control group(P=0.79). There was no statistical difference in the level of CD56 before and after treatment between the two groups(experimental group P=0.09, control group P=0.12). Conclusion Prednisone can improve the clinical outcome in patients with URSA, which may be related to the reduction of CD16 and inhibition of cell toxicity.

Key words: Unexplained recurrent spontaneous abortion, Prednisone, CD56, CD16, Natural Killer cell

CLC Number: 

  • R714.2
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