JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (7): 73-77.doi: 10.6040/j.issn.1671-7554.0.2015.049

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A feasibility study for boost target delineation using 18F-FDG PET/CT in local advanced non-small cell lung cancer

GAO Ang, WANG Shijiang, FU Zheng, SUN Xindong, YU Jinming, MENG Xue   

  1. Department of Radiation Oncology, Shandong Cancer Hospital; Shandong Academy of Medical Sciences, Jinan 250012, Shandong, China
  • Received:2015-01-13 Revised:2015-04-16 Published:2015-07-10

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Abstract: Objective To evaluate whether during-radiotherapy or post-radiotherapy 18F-FDG uptake locations within tumour can be identified by a pre-radiotherapy scan for non-small cell lung cancer, and to explore the optimal biological sub-volume of the primary tumor for dose escalation. Methods 18F-FDG PET/CT scans were performed at pre-radiotherapy, during-radiotherapy (40 Gy) or post-radiotherapy. The region of interests were auto-delineated using the 40%-70% maximal standardized uptake value (SUVmax) thresholds using pre-radiotherapy scan. Overlap fractions between pre-radiotherapy scan and during-radiotherapy or post-radiotherapy scan were calculated. Then, a Spearman correlation was used to analyze the correlations between the volumes of the region of interests and sensitivities of radiotherapy. Results The 50% SUVmax-delineated region of interests had large overlap fractions with the 40% SUVmax-delineated and manual-delineated regions of high uptake at during-radiotherapy, with the values being (74.3±15.9)% and (84.4±15.3)%, respectively. The overlap fractions of 50% SUVmax-delineated region of interests and the 80% SUVmax-delineated regions of high uptake at post-radiotherapy were more than 72%. The volume of 50% SUVmax-delineated region of interests was smaller than the gross tumor volume (GTV), with the value of being (29.4±12.3)%. However, the 50% SUVmax-delineated region of interests had no correlations with the sensitivities of radiotherapy. Conclusion A 18F-FDG PET/CT scan at pre-radiotherapy can identify the high 18F-FDG uptake regions at during-radiotherapy and post-radiotherapy. The 50% SUVmax-delineated volume may be a suitable region for dose boosting.

Key words: Dose painting, Non-small cell lung cancer, 18F-FDG-PET, Boost target delineation

CLC Number: 

  • R734.2
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