JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (10): 72-76.doi: 10.6040/j.issn.1671-7554.0.2014.222

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Value of acoustic radiation force impulse imaging technology for differentiating benign from malignant thyroid nodules

JIANG Lili1, MA Zhe2, MA Chuyun3, HE Yuanliu1, TAO Guowei2, LIU Cun1, GENG Qun4, TANG Tingting5, WANG Yin4   

  1. 1. Department of Ultrasonography, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    2. Department of Ultrasonography, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Department of Ultrasonography, Chengdu Military General Hospital, Chengdu 610083, Shandong, China;
    4. School of Medicine, Shangdong University, Jinan 250012, Shandong, China;
    5. Department of Ultrasonography, Jinan Fourth People's Hospital, Jinan 250031, Shandong, China
  • Received:2014-04-14 Revised:2014-09-11 Online:2014-10-10 Published:2014-10-10

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Abstract: Objective To evaluate the diagnostic value of virtual touch tissue quantification (VTQ) of acoustic radiation force impulse (ARFI) elasticity imaging for differentiating benign from malignant thyroid lesions. Methods Two hundred and sixty-eight patients with 312 thyroid nodules undergoing thyroid nodules surgeryor biopsies after thyroid nodules VTQ examination were retrospectively reviewed. The patients were selected from the Department of Ultrasonography, Qilu Hospital of Shandong University,during Sep. 2011 to Oct. 2012. All cases were divided into four groups, benign nodules group(n=196),parenchyma surrounding benign nodules group(n=196), malignant nodules group(n=116), and parenchyma surrounding malignant nodules group(n=116), according to the pathological results. TheVTQ values of the four groups were detected and statistically analyzed. Results ①VTQ value of malignant thyroid nodules group was significantly higher than those of the other groups(P<0.001);②No significant difference was found among the VTQ values of parenchyma surrounding benign nodules group, benign nodules group and parenchyma surrounding malignant nodules group(P=0.174, P=0.812, P=0.063);③According to the receiver operating characteristic(ROC) curve, 3.25 m/s was determined as the optimized point of the diagnostic value. When an SWV greater than 3.25 m/s was used for the diagnosis of malignant nodules and less than 3.25 m/s for the diagnosis of benign nodules, the sensitivity and specificity of ARFI imaging were 89% and 70%, respectively. Conclusion VTQ technology is more objective in quantitatively evaluating tissue hardness. VTQ technology shows better diagnostic value in the evaluation of benign and malignant thyroid nodules.

Key words: Acoustic radiation force impulse technology, Virtual touch tissue quantification, Differentiation, Thyroid nodules

CLC Number: 

  • R445.1
[1] 黄国良, 张怡. 甲状腺结节:手术还是观察?[J]. 中国实用内科杂志, 2010, 30(7):673-675. HUANG Guoliang, ZHANG Yi. Thyroid nodules: thyroidectomy or observation?[J].Chinese Journal of Practical Internal Medicine, 2010, 30(7): 673-675.
[2] 陈树强, 朱莉莉, 陈祥锦, 等. 声触诊组织定量技术诊断甲状腺乳头状癌[J].中国医学影像技术, 2011, 27(12):2451-2455. CHEN Shuqiang, ZHU Lili, CHEN Xiangjin, et al. Virtual touch tissue quantification in diagnosis of thyroid papillary carcinoma[J]. Chin J Med Imaging Technol, 2011, 27(12):2451-2455.
[3] 张凤娟, 韩若凌, 周军华, 等. 声触诊组织定量技术诊断甲状腺乳头状癌[J].中国医学影像技术, 2012, 28(5):877-880. ZHANG Fengjuan, HAN Ruoling, ZHOU Junhua, et al. Virtual touch tissue quantification in diagnosis of papillary thyroid carcinoma[J]. Chin J Med Imaging Technol, 2012, 28(5):877-880.
[4] Mandel S J.Diagnostic use of ultrasonography in patients with nodular thyroid disease[J]. Endocr Pract, 2004, 10(3):246-252.
[5] Sporea I, Vlad M, Bota S.Thyroid stiffness assessment by acoustic radiation force impulse electrograph (ARFI)[J]. Ultras hall Med, 2011, 32(3): 281-285.
[6] 王彬, 李发琪. 声辐射力弹性成像的新发展[J].中国医学影像技术, 2011, 27(4):853-854. WANG Bin, LI Faqi. Acoustic radiation force elastography:the new development of elastography[J]. Chin J Med Imaging Technol, 2011, 27(4):853-854.
[7] 王兴田, 王荣, 崔建华, 等. 正常人甲状腺剪切波速度参考值范围的初步研究[J]. 苏州大学学报:医学版, 2011, 31(6):958-960. WANG Xingtian, WANG Rong, CUI Jianhua, et al. Establishment of reference value of thyroid shear-wave velocity in healthy people[J]. Journal of Suzhou University(Medical Science Edition), 2011, 31(6):958-960.
[8] 肖莉莉, 赵雅萍, 高凌云, 等.声辐射力成像技术对甲状腺结节的研究应用[J].医学研究杂志, 2012, 41(5):126-130. XIAO Lili, ZHAO Yaping, GAO Lingyun, et al. Acoustic radiation force impulse technology: the application study of thyroid[J]. Journal of Medical Research, 2012, 41(5):126-130.
[9] Zhai L, Palmeri M L, Bouchard R R, et al. An integrated indenter-ARFI imaging system for tissue stiffness quantification[J]. Ultrason imaging, 2008, 30(2):95-111.
[10] McAleavey S A, Menon M, Orszlak J. Shear-modulus estimation by application of spatially-modulated impulsive acoustic radiation force[J]. Ultrasonic imaging, 2007, 29(2):87-104.
[11] Nightingale K, Soo M, Nightingale R, et al. Acoustic radiation force impulse imaging: in vivo demonstration of clinical feasibility[J]. Ultrasound Med Biol, 2002, 28(2):227-235.
[12] Sumi C.Regularization of tissue shears modulus reconstruction using strain variance[J]. IEEE Trans Ultrason Ferroelectr Freq Control, 2008, 55(2): 297-307.
[13] Bourchard R R, Dahl J J, Hsu S J, et al. Image quality, tissue heating, and frame rate trade-offs in acoustic radiation force impulse imaging[J]. IEEE Trans Ultrason Ferroelectr Freq Control, 2009, 56(1): 63-76.
[14] Barr R G, Destounis S, Lackey L I, et al. Evaluation of breast lesions using ultrasound elasticity imaging: a multicenter trial[J]. J Ultrasound Med, 2012, 31:281-287.
[15] 岳林先.实用浅表器官和软组织超声诊断学[M].北京:人民卫生出版社, 2011:180-181. YUE Linxian. Practical ultralsonography of superficial and soft tissue[M]. Beijing:people's medicalpublishing house, 2011:180-181.
[16] Friendrich-Rust M, Romenski O, Meyer G, et al. Acoustic radiation force impulse-imaging for the evaluation of the thyroid gland: a limited patient feasibility study[J]. Ultrasonics, 2012, 52(1):69-74.
[17] Barr R G. Shear wave imaging of the breast still on the learning curve[J]. Ultrasound, 2012, 31(3):347-350.
[18] Friendrich-Rust M, Wunder K, Kriener S, et al. Liver fibrosis in viral hepatitis noninvasive assessment with acoustic radiation force impulse imaging versus transient electrography[J]. Radiology, 2009, 252(2):595-604.
[19] D'Onofrio M, Gallotti A, Salvia R, et al. Acoustic radiation force impulse (ARFI) ultrasound imaging of pancreatic cystic lesions[J]. Eur J Radiol, 2011, 80(2): 241-244.
[20] Gallotti A, D'Onofrio, Pozzi Mucelli R. Acoustic radiation force impulse (ARFI) technique in ultrasound with virtual touch tissue quantification of the upper abdomen[J]. Radial Med, 2010, 115(6): 889-897.
[21] 郑剑, 曾婕, 郑荣琴, 等. 检测深度对肝脏实时剪切波弹性成像的影响[J]. 中华医学超声杂志(电子版), 2013, 10(8):647-651. doi:10.3877/cma.j.issn.1672-6448.2013.08.012. ZHENG Jian, ZENG Jie, ZHENG Rongqin, et al. Influence of depth on liver stiffness measurement with real-time shear wave elastography[J].Chinese Journal of Medical Ultrasound (Electronic Version), 2013, (8):647-651. doi:10.3877/cma.j.issn.1672-6448.2013.08.012.
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