Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (10): 72-79.doi: 10.6040/j.issn.1671-7554.0.2024.1336

• Clinical Medicine • Previous Articles    

Efficacy and safety of Babaodan Capsule in combination with mirabegron for the treatment of overactive bladder in women

JIA Zhencun1,2,3, WU Chenrui3, ZHAO Delong1, ZHU Kejia1, DING Sentai1,3   

  1. 1. Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    2. Department of Urology, Shenxian Peoples Hospital, Shenxian 252400, Shandong, China;
    3. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2025-10-17

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Abstract: Objective To investigate the clinical efficacy and safety of Babaodan capsule combined with mirabegron in the treatment of female overactive bladder syndrome(OAB). Methods A total of 60 female patients with OAB who were treated at the Affiliated Provincial Hospital of Shandong First Medical University from October 2021 to January 2023 were selected as the research subjects. They were divided into 2 groups by the random number table method: 30 cases received combined treatment with Babaodan and mirabegron(trial group), and 30 cases received combined treatment with placebo and mirabegron(control group), with a treatment course of 12 weeks. Before and after treatment, the overactive bladder syndrome score(OABSS), quality of life assessment(QOL), and micturition diaries were recorded. The levels of nitric oxide(NO), endothelin-1(ET-1), and inflammatory factors ［interleukin-6(IL-6), tumor necrosis factor-α(TNF-α)］ were detected. The clinical efficacy, incidence, and severity of adverse reactions were compared between the two groups. Results Four weeks and 12 weeks after treatment, the OABSS in the trial group was lower than that in the control group(P=0.001, P<0.001). The QOL scores of both groups were lower than those before treatment, and the trial group had a lower score than the control group(P<0.001). At 12 weeks after treatment, the expressions of TNF-α, IL-6, and ET-1 decreased, while the NO level increased in both groups, with statistically significant differences within the groups(P<0.001). The total effective rates of the trial group and the control group were 90.0% and 73.0%, respectively, with no statistically significant difference(P=0.182). During the treatment, neither group showed grade Ⅲ or above adverse reactions. Conclusion The combined use of Babaodan capsule and mirabegron in the treatment of female OAB can significantly alleviate clinical symptoms, shorten the treatment cycle, and reduce patient suffering, with better efficacy than mirabegron alone.

Key words: Babaodan capsule, Mirabegron, Female overactive bladder, Clinical efficacy

CLC Number: 

  • R694.5
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