Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (4): 87-90.doi: 10.6040/j.issn.1671-7554.0.2021.1416

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Effects of intense pulsed light on erythema telangiectasia rosacea observed with reflection confocal microscope

FAN Mengjiao1, HE Qin1, LUO Qing1, WANG Zhenhua2   

  1. 1. Weifang Medical University, Weifang 261000, Shandong, China;
    2. Department of Dermatology, The First Affiliated Hospital of Weifang Medical College(Weifang Peoples Hospital), Weifang 261000, Shandong, China
  • Published:2022-04-22

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Abstract: Objective To observe the changes of skin structure in patients with erythema telangiectasia rosacea before and after intense pulsed light(IPL)treatment observed with reflection confocal microscope(RCM), and to explore the therapeutic mechanism of IPL. Methods A total of 20 patients(35 to 46 years old, Fitzpatrick type Ⅲ to Ⅳ)with erythema telangiectasia rosacea who received IPL treatment for the first time were treated once every 4 weeks, 5 times in a course. The stratum corneum thickness, diameter of capillaries and density of dermal papilla were measured with RCM before the first treatment and 1 month after the last treatment. Results The stratum corneum thickness after IPL treatment was(4.97±0.65)μm, which was not significantly different from that before IPL treatment ［(5.11±0.54)μm］(P=0.249). The mean capillary diameter after treatment was(19.13±4.68)μm, which was significantly shorter than that before treatment ［(23.28±3.52)μm］(P<0.001). The dermal papilla density after treatment was(9.88±1.89)/mm2, which was significantly thicker than that before treatment ［(7.77±0.89)/mm2］(P<0.001). The skin aesthetic was significantly improved after treatment, and the patients had a high degree of acceptance of RCM examination and IPL treatment. Conclusion RCM can observe the structural changes of epidermis and superficial dermis of facial skin before and after IPL treatment without invasion. The therapeutic effects of IPL on erythema telangiectasia rosacea are related to the improvement of skin structure.

Key words: Rosacea, Intense pulsed light, Reflection confocal microscope, Skin structure

CLC Number: 

  • R758.73+4
[1] Chauhan N, Ellis DA. Rosacea: pathophysiology and management principles [J]. Facial Plast Surg Clin North Am, 2013, 21(1): 127-136.
[2] Papageorgiou P, Clayton W, Norwood S, et al. Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results [J]. Br J Dermatol, 2008, 159(3): 628-632.
[3] Nymann P, Hedelund L, Haedersdal M. Long-pulsed dye laser vs. intense pulsed light for the treatment of facial telangiectasias: a randomized controlled trial [J]. Eur Acad Dermatol Venereol, 2010, 24(2): 143-146.
[4] Wang X, Shu X, Li Z, et al. Comparison of two kinds of skin imaging analysis software: VISIA® from Canfield and IPP® from Media Cybernetics [J]. Skin Res Technol, 2018, 24(3): 379-385.
[5] Gupta AK, Chaudhry MM. Critical review of the manner in which the efficacy of therapies for rosacea are evaluated [J]. Int J Dermatol, 2003, 42(11): 909-916.
[6] Wilkin J, Dahl M, Detmar M, et al. Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea [J]. J Am Acad Dermatol, 2004, 50(6): 907-912.
[7] Kang HY, Bahadoran P, Ortonne JP. Reflectance confocal microscopy for pigmentary disorders [J]. Exp Dermatol, 2010, 19(3): 233-239.
[8] Ardigò M, Prow T, Agozzino M, et al. Reflectance confocal microscopy for inflammatory skin diseases [J]. G Ital Dermatol Venereol, 2015, 150(5): 565-573.
[9] Shahriari N, Grant-Kels JM, Rabinovitz H, et al. Reflectance confocal microscopy: principles, basic terminology, clinical indications, limitations, and practical considerations [J]. J Am Acad Dermatol, 2021, 84(1): 1-14.
[10] Wilkin J, Dahl M, Detmar M, et al. Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea [J]. J Am Acad Dermatol, 2002, 46(4): 584-587.
[11] Hegyi J, Hegyi V, Messer G, et al. Confocal laser-scanning capillaroscopy: a novel approach to the analysis of skin capillaries in vivo [J]. Skin Res Technol, 2009, 15(4): 476-481.
[12] Marson JW, Baldwin HE. Rosacea: a wholistic review and update from pathogenesis to diagnosis and therapy [J]. Int J Dermatol, 2020, 59(6): e175-e182.
[13] Moustafa F, Lewallen RS, Feldman SR. The psychological impact of rosacea and the influence of current management options [J]. J Am Acad Dermatol, 2014, 71(5): 973-980.
[14] Marson JW, Baldwin HE. Rosacea: a wholistic review and update from pathogenesis to diagnosis and therapy [J]. Int J Dermatol, 2020, 59(6): e175-e182.
[15] Tan J, Steinhoff M, Bewley A, et al. Characterizing high-burden rosacea subjects: a multivariate risk factor analysis from a global survey [J]. J Dermatolog Treat, 2020, 31(2): 168-174.
[16] Harper J, Del Rosso JQ, Ferrusi IL. Cross-sectional survey of the burden of illness of rosacea by erythema severity [J]. J Drugs Dermatol, 2018, 17(2): 150-158.
[17] Dirschka T, Micali G, Papadopoulos L, et al. Perceptions on the psychological impact of facial erythema associated with rosacea: results of international survey [J]. Dermatol Ther(Heidelb), 2015, 5(2): 117-127.
[18] Kawana S, Tachihara R, Kato T, et al. Effect of smooth pulsed light at 400 to 700 and 870 to 1,200 nm for acne vulgaris in Asian skin [J]. Dermatol Surg, 2010, 36(1): 52-57.
[19] Wenzel SM, Hohenleutner U, Landthaler M. Progressive disseminated essential telangiectasia and erythrosis interfollicularis colli as examples for successful treatment with a high-intensity flashlamp [J]. Dermatology, 2008, 217(3): 286-290.
[20] Huang YL, Liao YL, Lee SH, et al. Intense pulsed light for the treatment of facial freckles in Asian skin [J]. Dermatol Surg, 2002, 28(11): 1007-1012.
[21] Papageorgiou P, Clayton W, Norwood S, et al. Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results [J]. Br J Dermatol, 2008, 159(3): 628-632.
[22] Tsunoda K, Akasaka K, Akasaka T, et al. Successful treatment of erythematotelangiectatic rosacea with intense pulsed light: report of 13 cases [J]. J Dermatol, 2018, 45(9): 1113-1116.
[23] Papageorgiou P, Clayton W, Norwood S, et al. Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results [J]. Br J Dermatol, 2008, 159(3): 628-632.
[24] Sauermann K, Jaspers S, Koop U, et al. Topically applied vitamin C increases the density of dermal papillae in aged human skin [J]. BMC Dermatol, 2004, 4(1): 13.
[25] Bargo PR, Walston ST, Chu M, et al. Non-invasive assessment of tryptophan fluorescence and confocal microscopy provide information on skin barrier repair dynamics beyond TEWL [J]. Exp Dermatol, 2013, 22(1): 18-23.
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