Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (4): 68-75.doi: 10.6040/j.issn.1671-7554.0.2021.1619

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Diagnostic value of CT radiomics nomogram for adrenal lipid-poor adenoma and nodular hyperplasia

YUAN Hongtao1, JI Congshan1,2, KANG Bing1, QIN Songnan1, YU Xinxin1, GAO Lin2, WANG Ximing1,2   

  1. 1. Department of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong, China;
    2. Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2022-04-22

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Abstract: Objective To investigate the value of radiomics nomogram based on non-contrast CT in the differential diagnosis of adrenal lipid-poor adenoma and adrenal nodular hyperplasia. Methods Clinical data of 44 patients with adrenal lipid-poor adenoma and 55 with nodular hyperplasia confirmed by pathology were retrospectively analyzed. Radiomics features extracted from non-contrast CT and radiomics score(Radscore)were calculated to construct a radiomics model. Clinical factors were selected to construct a clinical model. Radiomics nomogram was constructed combining clinical factors and Radscore. The diagnostic values of the three models were compared. Results A total of 13 features were selected to establish the radiomics model. The area under the receiver operator characteristic curve(AUC), sensitivity and specificity of the radiomics model were 0.91, 84.6% and 81.3%, respectively. Both univariate and multivariate Logistic regression showed that renin and maximum diameter were the independent influencing factors in the differential diagnosis of adrenal lipid-poor adenoma and adrenal nodular hyperplasia. The AUC, sensitivity and specificity of the clinical model were 0.57, 53.9% and 68.8%. respectively. The AUC, sensitivity and specificity of the radiomics nomogram were 0.94, 84.6% and 93.8%, respectively. The diagnostic efficiency of the radiomics model and nomogram was significantly higher than that of the clinical model(z=3.188, P<0.001; z=3.409, P<0.001). Conclusion The radiomics nomogram based on non-contrast CT has a high efficiency in the differential diagnosis of adrenal lipid-poor adenoma and nodular hyperplasia.

Key words: Adrenal lipid-poor adenoma, Adrenal nodular hyperplasia, CT, Radiomics, Nomogram

CLC Number: 

  • R574
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