Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (11): 70-81.doi: 10.6040/j.issn.1671-7554.0.2022.0911

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Network pharmacologic mechanism of Huangqi Guizhi Wuwu Decoction in treating heart failure

FAN Xiaoyan1, WANG Yuangeng2, CHEN Zetao3   

  1. 1. The First Department of Cardiovascular Diseases, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China;
    2. First Clinical College of Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China;
    3. Geriatrics Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China
  • Online:2022-11-10 Published:2022-11-04

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Abstract: Objective To explore the mechanism of action of Huangqi Guizhi Wuwu Decoction(the Decoction)in the treatment of heart failure by using network pharmacology-molecular docking technique. Methods The drug components of the Decoction were obtained from the TCMSP database, the targets of drug components were obtained from the Uniprot database, the targets of heart failure were obtained from the GeneCard, OMIM, pharmgkb, TTD, DrugBank databases, and the common targets of the Decoction and heart failure were analyzed with R software. Protein-protein interaction(PPI), gene ontology(GO), Kyoto encyclopedia of genes and genomes(KEGG), and molecular docking analyses were performed using R, Cytoscape, Autodock, and pymol softwares. Results A total of 84 targets of the Decoction, 1,430 differential genes of heart failure, and 118 common targets were obtained. Pathway enrichment analysis of common targets showed that they were mainly related to mitogen activated protein kinase(MAPK)and interleukin-17(IL-17). The results of molecular docking showed that the core target of heart failure had good affinity with the main components of the Decoction, which could bind freely and effectively. Conclusion Quercetin, isorhamnetin and formononetin in the Decoction can play a role in the treatment of heart failure through anti-oxidative stress and anti-fibrosis. The Decoction has multi-level, multi-channel and multi-target effects on heart failure.

Key words: Heart failure, Huangqi Guizhi Wuwu Decoction, Network pharmacology, Molecular docking

CLC Number: 

  • R681.5
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