Abstract: Objective To evaluate the surgical and obstetrical outcomes of patients with early stage cervical cancer who underwent laparoscopic-assisted radical vaginal trachelectomy(LARVT). Methods A retrospective analysis was performed including young women with stage ⅠA1 and stage ⅠB1 cervical cancer who were treated with LARVT at the Department of Obstetrics and Gynecology, Peking Union Medical College Hospital from January 2003 to January 2017. Results Eighty-eight patients with early stage cervical cancer(ⅠA1, n=5; ⅠA2, n=8; ⅠB1, n=75)were selected as candidates for the inclusion criteria during the period analyzed. The patients’ average age was 30.9 years(range, 18-44 years). Histology included 68 cases with squamous cell carcinoma, 14 cases with adenocarcinoma, 3 cases with adeno-squamous carcinoma, and 3 cases with clear cell carcinoma. Twelve patients(13.7%)had a tumor >2 cm and 76 cases had a tumor ≤ 2 cm. The median duration of follow-up reached 54.1 months(2.0-176.9 months). Eleven patients(12.5%)had recurrent diseases. The median interval between the initial surgery and recurrence was 34.1 months(range, 9.3-90.1 months). A total of 40 patients had attempted to conceive, resulting in 21 pregnancies and 15 healthy babies. Conclusion LARVT should be offered as an alternative treatment for women with early stage cervical cancer who want to preserve their fertility. The oncologic outcome and pregnancy outcome should be further investigated for long-term follow-up.

Key words: Cervical cancer, Radical trachelectomy, Fertility preservation, Laparoscopy, Neoplasm recurrence, local, Pregnancy outcome