Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (10): 93-102.doi: 10.6040/j.issn.1671-7554.0.2017.1017

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Consumption of soybean products and gastric cancer risk: a systematic review and meta-analysis

NI Yingchun1, YANG Xiaorong1, DU Jinge2, LÜ Ming1,3   

  1. 1. Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Infection Control Unit, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2017-10-23 Online:2018-10-10 Published:2022-09-27

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Abstract: Objective To investigate the association between consumption of soybean products and risk of gastric cancer(GC). Methods Relevant literature was searched in PubMed, Web of Science, Embase, CNKI and Wanfang Database from the inception to March 2017. The association between soybean product consumption and GC risk was analyzed with pooled odds ratio(OR)and 95% confidence interval(CI). Subgroup analyses were further performed according to different types of design, genders and geographic regions. Results A total of 53 studies were obtained, including 18 cohort studies with 5 153 cases and 890 145 participants, and 35 case-control studies with 10 692 cases and 25 324 controls. Finally 3 studies with low quality were excluded and 50 studies were included in the systematic review and meta-analysis. The results indicated that higher soybean, tofu and soybean milk consumptions were associated with a decreased risk of GC(soybean, OR=0.75, 95%CI: 0.66-0.85; tofu, OR=0.77, 95%CI: 0.68-0.88; soybean milk, OR=0.78, 95%CI: 0.65-0.94). Subgroup analyses suggested that higher soybean and tofu consumptions were negatively associated with GC risk(soybean, OR=0.80, 95%CI: 0.74-0.86; tofu, OR=0.77, 95%CI: 0.68-0.88)among Asians. Conclusion High intake of soybean, tofu and soybean milk can reduce the risk of GC.

Key words: Soybean products, Gastric cancer, Risk, Meta-analysis

CLC Number: 

  • R181.3
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