JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Effects of erythropoietin on heme oxygenase-1 expression in rats with globle ischemia-reperfusion injury

HUANG Tao1，LIN Xiao-ying2，LI Fang-lin1，ZHONG Ning1，LIU Yun-fang1，MENG Xiao-hui1，ZHENG Yu-lan1，SONG Wen-yan1   

  1. 1． Department of Diagnostics, School of Medicine, Shandong University， Jinan 250012, China;2. Department of Neurology, Jinan Central Hospital, Jinan 250013, China
  • Received:2007-09-19 Revised:1900-01-01 Online:2008-03-16 Published:2008-03-16
  • Contact: LI Fang-lin

PDF (PC)

264

Abstract: To explore the effect of erythropoietin（EPO）treatment on the expression of heme oxygenase-1（HO-1）mRNA in rats with globe ischemia-reperfusion injury. Methods The 4-vessel obstructive globe ischemic rat models were used in this study. The rats were randomly divided into three groups: the ischemia-reperfusion group, the experimental group and sham-operation group. Rats in the ischemiareperfusion group and the experimental group were subjected to EPO injection into the abdominal cavity after globe ischemia, however rats in the sham-operation group were not subjected to an operation. The expression of HO-1 mRNA was determined by RT-PCR. Results① After ischemia, the expression of HO1 mRMA was obviously changed based on time. ② The effect of EPO treatment on the expression of HO-1 mRNA in the cortex of this rat model was obvious. ConclusionThe protective effect of EPO for ischemiareperfusion injury is perhaps induced by up-regulating the expression of HO-1.

Key words: Heme oxygenase(Decyclizing), Erythropoietin, Reperfusion injury

CLC Number: 

  • R743.33
[1] LONG Tingting, XIE Ming, ZHOU Lu, ZHU Junde. Effect of Noggin protein on learning and memory abilities and the dentate gyrus structure after cerebral ischemia reperfusion injury in mice [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 15-23.
[2] LIU Fang, QIAO Lei, CHEN Wenchao, YANG Lina. Cardioprotective effects of allicin postconditioning on myocardial ischemia-reperfusion injury in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 6-11.
[3] LIANG Lining, ZHONG Xia, JI Xianfei, HU Haoran, ZHU Fangfang, CHEN Jibin,CHEN Qianqian, SHANG Deya. Protective effects of post-conditioning with nicorandil on myocardial, cerebral and renal ischemia-reperfusion injury following cardiac arrest in swine [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 46-51.
[4] ZHU Jing, GUO Aili, ZHANG Nan, QIN Mingming, LIU Lijuan, ZHU Weiwei. Effect of erythropoietin on hypoxic ischemic encephalopathy in neonates [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 60-63.
[5] LI Xin, WANG Gongming, WANG Hong, WANG Yan, ZHANG Ligong, ZHANG Le, LIU Bei, ZHANG Mengyuan. Inducible nitric oxide synthase contributes to the delayed cardioprotection of ischemic postconditioning in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 16-20.
[6] LI Shaowei, LIU Zongzheng, LIU Chunxia, ZHANG Yanru, ZHOU Huanmin. Protective effect of grape seed proanthocyanidins in mouse fatty liver models suffering ischemia-reperfusion injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(9): 41-46.
[7] LI Minghua, WANG Jiali, XU Feng, YUAN Qiuhuan, LIU Baoshan, PANG Jiaojiao, ZHANG Yun, CHEN Yuguo. Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury by inhibiting aldehyde dehydrogenase 2 activity in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 15-20.
[8] LI Shaowei, LIU Zongzheng, LIU Chunxia, ZHANG Yanru, ZHOU Huanmin. Hydrogen-rich water alleviates ischemia-reperfusion injury in mice with fatty liver [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(1): 10-15.
[9] LIU Shan-wen1, WANG Fu1, LI Bin2, GENG Hai-hua3, LI Cai-e4, XU Zhe5, LI Rui1, XIAO Jie1, ZHANG Sen1, JI Xiao-ping1. Isolation of rat bone marrow mesenchymal stem cell-derived exosome and the uptake of exosome by H9C2 [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(9): 1-7.
[10] GE Jun-ke, ZHAO Sheng-tian. Protective effect of bone marrow mesenchymal stem cells and CD133+ renal cells on acute renal injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(9): 55-59.
[11] JIN Bin1, WANG Wei2, LIU Ze-yang1, LI Guang-zhen1, DU Gang1, ZHANG Zong-li1, HAN Li-tao1, HUANG Guo-zhen1, TANG Zhen-yu1. Protection against ischemiareperfusion injury in aged liver donor by induction of exogenous hTERT gene [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(8): 13-16.
[12] WANG Fu1, LIU Shan-wen1, LI Bin2, GENG Hai-hua3, SUN Shuai1, LI Rui1, XIAO Jie1， JI Xiao-ping1. Protective effects of rhEPO on oxidative stress damage in cardiomyocytes and on heart after myocardial infarction [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(7): 1-5.
[13] DING Ming1， ZONG Bo1， WANG Xue-ping2. Protective mechanisms of fentanil and methylprednisolone sodium succinate
on ischemia-reperfusion injury after rabbit limb replantation [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(9): 55-58.
[14] WANG Lei, GUAN Guang-ju. Effect of rHuEPO on the proliferation and TGF-β mRNA expressions of
rat mesangial cells induced by high glucose [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(5): 65-69.
[15] CAO Li-jun1, WANG Jin2, SUN Chun-li1, CHEN Yu-guo1. Mechanism and protective effect of ulinastatin on synaptic function of
hippocampus after focal brain ischemiareperfusion injury in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 6-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd