JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (4): 60-63.doi: 10.6040/j.issn.1671-7554.0.2015.1200

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Effect of erythropoietin on hypoxic ischemic encephalopathy in neonates

ZHU Jing1, GUO Aili2, ZHANG Nan2, QIN Mingming2, LIU Lijuan3, ZHU Weiwei2   

  1. 1. Taishan Medical University, Taian 271000, Shandong, China;
    2. Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    3. School of Medicine, Shandong University School of Medicine, Jinan 250012, Shandong, China
  • Received:2015-12-01 Online:2016-04-10 Published:2016-04-10

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Abstract: Objective To observe the curative effect of erythropoietin(EPO)in the treatment of neonatal hypoxi-ischemic Encephalopathy(HIE). Methods A total of 81 cases of neonatal HIE were randomly divided into EPO treatment group(n=42)and control group(n=39), and healthy full-term neonates born during the same period were randomly selected as the normal control group. The control group and treatment group were given conventional treatment. Besides that, the EPO treatment group was intravenously injected with EPO 200 IU/kg a day, 3 times a week for 2 weeks. All patients undertook neonatal behavior neurological determination(NBNA)on day 7, 14 and 28 after birth, and received infant intelligence development assessment(CDCC)3 and 6 months after birth. All babies were followed up 6 and 12 months after birth. Results The NBNA score 7 days after birth had no statistical difference between the treatment group and control group, which was lower than that of normal group(P<0.01). The treatment group had higher NBNA scores 14 and 28 days than the control group(P<0.05), which were still lower than those of the normal group(P<0.01). The treatment group had higher CDCC score 3 months after birth than the control group(P<0.05), which was lower than that of the normal group(P<0.01). Six months after birth, the CDCC score of the treatment group was significantly higher than that of the control group(P<0.05), and there was no difference between the normal group and normal group in MDI, but the PDI of the treatment group was still lower than that of the normal group(P<0.05). 山 东 大 学 学 报 (医 学 版)54卷4期 -朱静,等.促红细胞生成素治疗新生儿缺氧缺血性脑病的疗效观察 \=- Conclusion The efficacy of EP0 works more effectively than ganglioside therapy in treatment of neonatal HIE.

Key words: Hypoxic-ischemic encephalopathy, Neonate, Erythropoietin

CLC Number: 

  • R725
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