JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (12): 37-40.doi: 10.6040/j.issn.1671-7554.0.2016.606

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Correlation between serum prealbumin and neonatal behavioral neurological assessment of hypoxic-ischemic encephalopathy in neonates

ZHUANG Genmiao1, TANG Ling2, ZANG Lijiao2, AN Li2   

  1. 1. Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    2. School of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2016-05-24 Online:2016-12-10 Published:2016-12-10

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Abstract: Objective To analyze the association between serum prealbumin(PA)level and neonatal behavioral neurological assessment(NBNA)in neonates with hypoxic-ischemic encephalopathy(HIE). Methods A total of 24 neonates including 11 males and 13 females were selected from HIE newborns admitted to Jinan Central Hospital during Jan. 2014 and Dec. 2015. The neonates were divided into 3 groups according to the HIE diagnostic criteria and dinical grading in 2005, mild(n=11), moderate(n=9), and severe(n=4), and another 20 healthy newborns served as controls. Blood samples and NBNA scores were collected from all newborns on day 1, 3, and 10 after birth, to detect the serum PA values. Results The Bonferronis test indicated that on day 1 and 3, there existed such relationship among PA level of 4 groups: PA(severe)< PA(moderate)< PA(mild)< PA(control),(P<0.01), so did NBNA scores on day 1, 3 and 10(P<0.01). Besides, the Pearsons Correlation Coefficient test showed significant positive linear correlation between PA level and NBNA scores of each HIE group, on day 1(r=0.554, P<0.01), after treatment, and day 10(r=0.344, P<0.01). Conclusion As the clinical grading becomes higher, the serum 山 东 大 学 学 报 (医 学 版)54卷12期 -庄根苗,等.新生儿缺氧缺血性脑病中血清前白蛋白水平与新生儿行为神经测定的相关性 \=-PA values and the NBNA scores are lower. Along with the recovery of disease, the serum PA values and NBNA scores gradually increase. The serum PA combined with NBNA scoring could be used as the indicator of early diagnosis and prognostic evaluation of neonatal HIE.

Key words: Newborn, Neonatal behavioral neurological assessment, Nutrition support, Prealbumin, Hypoxic-ischemic encephalopathy

CLC Number: 

  • R772.1
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