JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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TAFI level and its mechanism in the process of atherosclerosis in rats

LIU Li-yan, LIU Xiang-qun, CHEN Xiao-an, CHEN Huan-qin   

  1. Department of Geriatrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2006-12-26 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
  • Contact: LIU Xiang-qun

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Abstract: Objective: To investigate the level of TAFI and its mechanism on atherosclerosis. Methods: Forty healthy male Wistar rats were randomly divided into 4 groups (n=10): the control group, the high lipid group, the high lipid + Vitamin D overload group, and the endothelium injury group. Then the content of TC, TG, HDL-C, and LDL-C and the activity of TAFI were determined by a chromogenic assay. Results: Atherosclerosis was successfully established. Hyperlipoidemia stage, fiber hyperplasy arteriosclerosis stage and maturatly plaque stage were also successfully duplicated. TC, TG, LDL-C and the activity of TAFI in the plasma of the three model groups gradually increased compared with the control group （P＜0.01). However, HDL-C in the plasma of the three model groups gradually decreased compared with the control group（P＜0.01 or P＜0.05). The activity of TAFI in the plasma positively related to TG and TC. Conclusion: The activity of TAFI in the plasma is closely correlated with atherosclerosis severity.

Key words: Atherosclerosis, Thrombin activatable fibrinolysis inhibitor, Endothelium, Injuries, Rats, Wistar

CLC Number: 

  • R541.4
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