JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of vitamin B on hyperhomocysteinemia in renal-transplant recipients

ZHAO Jing-jie1，LIU Jun-li1，TIAN Chuan2，ZHANG Cai3   

  1. 1. Laboratory of Clinical Molecular Biology, Second Hospital of Shandong University；2. Transplant Center, Second Hospital of Shandong University；3. Institute of Immuno-pharmacology and Immunotherapy, School of Pharmacy
  • Received:2007-06-12 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
  • Contact: ZHANG Cai

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Abstract: Objective: To explore the effect of folic acid, Vit B6, and Vit B12 on hyperhomocysteinemia in renal-transplant recipients. Methods: 195 renal-transplant recipients were randomly divided into the vitamin treatment group (group A, n=103, folic acid 5mg/d, vitamin B6 50mg/d, Bl2 1mg/d, totally 2 months) and the control group (group B, n=92)． The plasma Hcy levels were determined before treatment, before operation and 1, 10, 20 and 30 days after operation. Results: The plasma level of Hcy in group B was significantly higher than that in group A before and after operation. The rate of acute rejection was lower in group A than in group B. Conclusion: Vitamin B supplementation can reduce the homocysteine level and the rate of acute rejection for renal-transplant recipients．

Key words: Homocysteine, Vitamins, Kidney transplantation

CLC Number: 

  • R699.2
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