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Changes of electrophysiology of the sciatic nerve and expression of GAP-43 protein in injured spinal cord tissue of rats

XIE Xiao1，GAO Jian-xin1，LIU Ke-jing1，YU Hui2，YANG Gui-zhong3   

  1. 1. Institute of Physiology; 2. Morphological Laboratory; 3.Functional Laboratory, School of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2006-11-20 Revised:1900-01-01 Online:2007-05-24 Published:2007-05-24
  • Contact: GAO Jian-xin

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Abstract: Objective: To investigate the changes of threshold, amplitude and conduction velocity of the action potential (AP) in the sciatic nerve and the expression of GAP43 protein in rats with spinal cord injury (SCI). Methods: Electrophysiological and immunohistochemistry techniques were used in experimental rats that were induced by the Allen＇s spinal cord weight-drop-injury method. Results: The increase of threshold, the decrease of amplitude and conduction velocity of AP in the sciatic nerve showed a time-dependent manner at 1d, 3d and 7d following SCI. However, the above changes attenuated at 14d following SCI. Expression of GAP-43 proteins progressively increased at 1d, 3d, and 7d following SCI, and reached a peak at the 7th d. Conclusion: The excitability and conductibility of the sciatic nerve degrade and the expression of GAP-43 protein increases following SCI in rats .

Key words: Spinal cord injury, Sciatic nerve, Action potential, GAP-43, Rats

CLC Number: 

  • Q42
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