JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Correlation of Angiotension Ⅱ and its type Ⅰreceptor gene polymorphisms with HBV-induced liver cirrhosis

LI Hua1，ZHAO You-an2，LV Hui3，WU Hong-lei4，WANG Hong-bo4   

  1. Department of Gastroenterology, 1. Affiliated Xiamen First Hospital, Fujian Medical University；2. Qilu Hospital of Shandong University；3. Jinan Hospital of Infectious Disease；4. Second Hospital of Shandong University
  • Received:2006-08-08 Revised:1900-01-01 Online:2007-03-24 Published:2007-03-24
  • Contact: LI Hua

PDF (PC)

878

Abstract: Objective: To investigate the correlation of polymorphisms of 1166 A/C of Angiotensin Ⅱ type Ⅰ receptor gene ( AT1R 1166A/C) and angiotensin Ⅱ with hereditary susceptibility and clinical phenotype of HBV-induced liver cirrhosis. Methods: Peripheral blood samples were collected from 102 patients with HBV-induced liver cirrhosis and 106 healthy donors. Polymorphisms of the 1166A/C of AT1R gene were determined by PCR-RFLP, and plasma concentrations of Angiotensin Ⅱ were measured by RIA. Results: Plasma concentrations of angiotensin Ⅱ of the liver cirrhosis group were significantly higher than those of the control group (P＜0.05). Plasma concentrations of angiotensin Ⅱ were also significantly higher in patients with the Child-Pugh C and B grades than those in patients with the Child-Pugh A grade (P＜0.01 and P＜0.05, respectively). They were also higher in patients with severe esophageal varices and an ascites than those with light esophageal varices and without ascites (P＜0.05). There was not a significant difference in genotype and allele frequency of AT1R 1166A/C between the liver cirrhosisgroup and the control group (P＞0.05). Conclusion: Plasma concentration of angiotensin Ⅱ is related to the progression of liver cirrhosis and the 1166A/C polymorphism of the AT1R gene is not related to hereditary susceptibility or progression of liver cirrhosis.

Key words: epatitis B, Liver cirrhosis, Angiotensin Ⅱ, Receptors, angiotensin

CLC Number: 

  • R575.2
[1] WUYi-Na, GE Zhi-Ming, LI Fang, HE Hong, JIANG Hong, ZHANG Yun. Expressions of angiotensin converting enzyme 2 mRNA and protein in the kidneys in spontaneously hypertensive rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 5-.
[2] ZHANG Dao-Lai, SUN Tao, XIE Shan-Shan, WANG Yu-Zhuo, ZHAO Ling, FENG Yu-Xin, XIN Hua. Developmental expression of NMDAR1 subunit on cultured cerebral cortical neurons of fetal rats in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 28-32.
[3] WANG Shao-Qing, LIU Yi-Hui, FU Ting-Ting, CHENG Jin-Yong, LIU Qiang. Classification of 31P MRS data for hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 42-46.
[4] LIU Qiuxia, WANG Lei, LIU Feng, QU Yundong, YE Qian, QIAN Yu, ZHANG Yuan, ZHANG Lixin. Hypophosphatemia during long-term adefovir dipivoxil therapy in patients with hepatitis B virus infection [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 73-78.
[5] GAO Jianbu, YANG Shouzhong, LI Yudong, QIAO Chong, ZHANG Songyu. Trend survey of inpatient use of drugs for acute myocardial infarction during 10 years in a hospital of Nanyang City [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 66-69.
[6] JIA Jiajing, WANG Zhiping. Effects of high exposure of endogenous reproductive hormones on perimenopausal and postmenopausal blood pressure in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(11): 7-14.
[7] ZHAO Lu, JIAO Jun, ZHANG Teng, JIAO Xinlin, CUI Baoxia. Expression of LXRα in ovarian carcinoma and effects of T0901317 on SKOV3 cell line [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 49-53.
[8] WEI Dandan, ZHANG Cheng. Effects of the overexpression of type 4 angiotensin receptor on the formation of atherosclerotic lesions [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 1-5.
[9] ZHANG Kun, ZHAGN Xiaoguo, CUI Xingxing, CHEN Shijun. Expression of apoptosis-related genes in peripheral blood mononuclear cells of patients with HBV infection and the relationship with chronicity of hepatitis B [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 38-42.
[10] GUAN Jingyun, YANG Yang, QIU Chunhong, LI Xiangzhi. Role of histone acetyltransferase MOF in the pathogenesis of multiple sclerosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 27-32.
[11] QIAN Yu, QU Yundong, WANG Ziyu, LIU Feng, YE Qian, WANG Lei. Risk factors to influence renal function of patients with chronic hepatitis B virus infection [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 29-32.
[12] LIU Leilei, JU Yunfei, XU Wenfei, JU Yuanrong. Protective effect and possible mechanism of losartan on endotoxin-induced acute lung injury in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 6-11.
[13] WANG Fuying1, LIU Xiaomeng2, DONG Qingyu2, LIANG Cuige2, DU Wenhua2, WANG Yueli2, LI Wenxia2, GAO Guanqi2. Dynamic changes of serum TRAb concentration after 131I treatment of Graves’ disease and its association with early hypothyroidism [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(6): 55-57.
[14] LIU Tongyan1, ZHANG Longyue2, LI Yuerong3, SUN Jingli2, HAN Zenglu3, LI Zhiquan1, ZHANG Lixin1, WANG Lei1. Prospective cohort observation of patients with hepatitis B e antigen-positive chronic hepatitis B treated by Adefovir dipivoxil and Interferon-α [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(6): 72-78.
[15] WU Shanbin, XU Hongwei, LIU Hui, LI Bin. Endoscopic injection sclerotherapy performed both by intravariceal and paravariceal injection for esophageal variceal hemorrhage#br# [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(6): 85-89.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd