JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (1): 29-32.doi: 10.6040/j.issn.1671-7554.0.2015.413

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Risk factors to influence renal function of patients with chronic hepatitis B virus infection

QIAN Yu, QU Yundong, WANG Ziyu, LIU Feng, YE Qian, WANG Lei   

  1. Department of Hepatology, The Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Received:2015-04-24 Online:2016-01-11 Published:2016-01-11

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Abstract: Objective To assess the renal function of patients with chronic hepatitis B virus(HBV)infection and to explore the risk factors for renal dysfunction. Methods A total of 206 treatment-naïve patients with chronic HBV infection were enrolled, including 151 cases of chronic hepatitis B(CHB)and 55 cases of liver cirrhosis. The renal function with estimated glomerular filtration rate(eGFR)was calculated with latest Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)equation. The prevalence of renal impairment ［eGFR < 90 mL/(min·1.73 m2)］ was evaluated and risk factors for renal abnormalities were analyzed. Results The total incidence of renal impairment was 21.85%(45/206), while it was 17.88%(27/151)and 32.73%(18/55)among CHB patients and liver cirrhosis patients, with the latter being significantly higher than the former(χ2= 5.205, P=0.023). Age(≥50 years)and history of hypertension were identified as risk factors for renal impairment. Conclusions Renal abnormalities pre-exist in some patients with chronic HBV infection before the initiation of any antiviral treatment. Age and history of hypertension are identified as risk factors for renal impairment. We need to evaluate renal function in patients with chronic HBV infection at baseline and monitor renal function regularly.

Key words: Glomerular filtration rate, Renal function impairment, Chronic hepatitis B

CLC Number: 

  • R512.6+2
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