JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (1): 22-28.doi: 10.6040/j.issn.1671-7554.0.2015.303

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Preparation and pharmacokinetics of baicalin lipid nanocapsules

MU Jun1,2, SHAN Lina3, ZHAI Yingjie2, ZHAI Guangxi2   

  1. 1. Department of Pharmacy, Shengbei Hospital, Shengli Petroleum Administrative Bureau, Dongying 257064, Shandong, China;
    2. Department of Pharmaceutics, College of Pharmaceutical Science, Shangdong University, Jinan 250012, Shandong, China;
    3. Department of Traditional Chinese Medicine, Shengbei Hospital, Shengli Petroleum Administrative Bureau, Dongying 257064, Shandong, China
  • Received:2015-03-20 Online:2016-01-11 Published:2016-01-11

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Abstract: Objective To prepare the novel baicalin-lipid nanocapsules(BA-LNC)and to detect the physical and chemical properties and the pharmacokinetics. Methods With the medium chain triglyceride(MCT)as oil phase,polyethylene glycol monostearate as surface active agent, lecithin as auxiliary emulsifier, lipid nanocapsules(LNC)were prepared by the phase inversion method and evaluated with encapsulation efficiency(EE)and drug loading(DL). The formulation was optimized by the simplex lattice method and the optimal prescription was obtained by a response surface method. The pharmacokinetic study was also conducted in Wistar rats to explore the potential of LNC as carriers of baicalin. Results The EE was 92.58% and the DL was 1.69%. Under the transmission electron microscope, BA-LNC was spherical without adhesion. The average particle size was(84.2±1.7)nm with the polydispersity index being 0.201, and the Zeta potential was(-13.2±0.62)mV. BA-LNC could significantly prolong the residence time of drug in vivo, and obviously improve the oral absorption of baicalin. Conclusion The prepared lipid nanocapsules can obviously increase the oral bioavailability of baicalin.

Key words: Baicalin, Phase inversion-based method, Simplex lattice, Lipid nanocapsules

CLC Number: 

  • R944.1
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