JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Effect of long-term ethanol feeding on glycogen and structures of the livers of Wistar rats

CHEN Shao-hua1,3,ZHAO Jia-jun1，FENG Li1,HOU Xiao-lei2，ZHANG Wei3,YU Hui3，GAO Ling2   

  1. 1. Department of Endocrinology, Shandong Provincial Hospital; 2. Institute of Pharmacology, Shandong Provincial Hospital; 3.Department of Endocrinology, Qianfoshan Hospital of Shandong Province
  • Received:2007-06-24 Revised:1900-01-01 Online:2007-11-24 Published:2007-11-24
  • Contact: CHEN Shao-hua

PDF (PC)

960

Abstract: ObjectiveTo investigate the effects of a long-term ethanol feeding on the glycogen content and structure of the liver in rats. Methods48 rats were randomly divided into 4 groups: the ethanol groups A, B and C and the control group. Rats were subjected to ethanol of 0.5, 2.5, and 5g/(kg·d) in the experimental groups respectively and saline in the control group for 5 months. Different physical parameters, HE staining, PAS staining and the glycogen content( Colorimetry, SpectraMax M2，) were determined. ResultsCompared with group D, groups A, B and C showed a lower weight of body and liver. Glycogen levels of groups A, B and C decreased, and the glycogen decreased in an ethanol dosedependent manner. HE staining showed lots of lipid vacuoles and inflammatory cells in groups A, B and C relative to group D. On the other hand, PAS staining revealed a decrease of glycogen granules. ConclusionLong-term intake of ethanol influences the glycogen content and causes some damage to the structure of liver tissues.

Key words: Ethanol, Liver, Glycogen, Wistar rats

CLC Number: 

  • R575.5
[1] WANG Shao-Qing, LIU Yi-Hui, FU Ting-Ting, CHENG Jin-Yong, LIU Qiang. Classification of 31P MRS data for hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 42-46.
[2] JIANG Zheng, SHEN Zhenwei, ZHANG Guang, LI Runzi, CAO Jin, WANG Li, XUE Fuzhong, LIU Yanxun. Construction of a NAFLD screening tool based on health examination subjects [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(6): 114-118.
[3] LIU Xiaojuan, JIANG Zheng, KANG Fengling, ZHOU Miao, LIN Weiqiang, XUE Fuzhong. Association between neutrophil count and nonalcoholic fatty liver disease:a prospective cohort study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(6): 119-123.
[4] ZHANG Yu, HAN Chen, WANG Zhaoxia, WANG Zhaopeng, ZHANG Yueying, ZHOU Shuping, MA Ranran, WANG Hengxiao. Protective effects of Tamarix chinensis Lour on mice with alcoholic liver injury and its mechanism [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 61-67.
[5] WANG Bishi, SHAN Junqi, HOU Qingsheng, GONG Weipeng, ZHU Zhenyu, GUO Hongliang. Effort of CD11b+ / CD66b- phenotype myeloid cells on the progression of colon cancer and liver metastasis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 41-45.
[6] ZHAO Lu, JIAO Jun, ZHANG Teng, JIAO Xinlin, CUI Baoxia. Expression of LXRα in ovarian carcinoma and effects of T0901317 on SKOV3 cell line [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 49-53.
[7] ZHAN Fengxia, DING Juan, MA Beilei, WANG Qian. Effects of estradiol on Th1 cell polarization and liver fibrosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 64-68.
[8] SHEN Zhenwei, JI Xiaokang, WANG Qinglian, LI Jie, XUE Fuzhong, LIU Jing. Association between nonalcoholic fatty liver disease and chronic kidney disease: a retrospective cohort study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 43-49.
[9] LIN Dong, GUAN Qingbo. Association of serum testosterone level and non-alcoholic fatty liver disease in male patients with T2DM [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 33-37.
[10] ZHANG Weiling, LIU Xiaojuan. Preparation of self-microemulsifying drug delivery system for quercetin [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(3): 41-44.
[11] FANG Feifei, ZHANG Ying, LIN Qi, YUAN Yuan, DAI Jianjian, XU Ruicai, GENG Baocheng, HAN Mingyong. Clinical efficacy of CT-guided 125I seed brachytherapy in the treatment of metastatic hepatic carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 53-57.
[12] YU Ning, GAO Yanyan, XIAN Yuxin, NIU Jiapeng, LI Li, WANG Jing, CAO Caixia. Effect of exenatide on serum chemerin level and liver fat contents in type 2 diabetes mellitus combined with non-alcoholic fatty liver disease patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 51-55.
[13] YANG Hui, DONG Rong, XUE Hui, HU Zuquan, ZENG Zhu. Gene microarray analysis of mature dendritic cells cultured with hepatocellular carcinoma cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 1-6.
[14] LI Shaowei, LIU Zongzheng, LIU Chunxia, ZHANG Yanru, ZHOU Huanmin. Protective effect of grape seed proanthocyanidins in mouse fatty liver models suffering ischemia-reperfusion injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(9): 41-46.
[15] WANG Xiaoyue, WANG Daoguang, GUO Jisheng, LI Cuiling, JING Ruirui, LÜ Xin, CHEN Xinjun, YANG Jinghua. Label-free quantification of proteomic changes in ethanol-induced hepatocyte [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(3): 12-16.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd