JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression of IL10 in gingival lesion in adult periodontitis

CHENG Pei-hong1,QI Xiang-min2,SUN Shan-zhen3   

  1. 1. Department of Oral Medicine, Qilu Hospital of Shandong University;2. Department of Periodontal Membrane, School of Stomatology, Shandong University;3. Department of Pathology, School of Stomatology, Shandong University, Jinan 250012, Shandong, China
  • Received:2006-02-19 Revised:1900-01-01 Published:2006-06-25
  • Contact: CHENG Pei-hong

Abstract: To investigate the expression of IL10 in gingival tissues of various clinical stages in adult periodontitis. Methods: Immunohistochemistry SABC method was used to semiquantitatively measure the expression of IL10 in 24 adults with periodontits(12 in periodontal abscess group and 12 in treatment group), 10 patients with gingivitis and 6 healthy controls. Results: The quantity of IL10 was lower in abscess group than that in healthy controls, gingivitis and treatment group, respectively (P＜0.05, P＜0.01, P＜0.01), and it was significantly higher in treatment group than that in healthy controls and gingivitis group (P＜0.01, P＜0.01). Conclusion: The expression of IL10 decreases in the activity of periodontitis, but increases after treatment, suggesting IL10 acts as a protective role in the restoration of periodontal tissues.

Key words: Interleukin10, Periodontitis, Adult, Gingiva, Tissues

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