JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Experimental study of Metoprolol on cardiac fibrosis in rabbits with acute myocardial infarction

WANG Qing, SUN Xue-lin, XING Qi-chong, YAN Su-hua, HU He-sheng   

  1. Department of Cardiology, Qianfo Mountains Hospital, School of Clinical Medicine, Shandong University, Jinan250014,Shandong, China
  • Received:2005-09-01 Revised:1900-01-01 Online:2006-12-24 Published:2006-12-24
  • Contact: WANG Qing

Abstract: To investigate the precautionary and therapeutic action of Metoprolol on collagen remodeling after acute myocardial infarction(AMI) in New Zealand rabbits. Methods： MI was established by ligating the left ventricular branch of coronary artery in 24 New Zealand rabbits who were randomly divided into 2 groups, Metoprolol group and AMI group. And the other 8 rabbits were enrolled into sham operation group. After test, 8 rabbits survived in Metoprolol group, 10 in AMI group, and 7 in sham operation group. The serum level of IL6 was measured before operation, 1 day and 4 days after operation, and the level of hsCRP before operation, 1 day and 7 days after operation. The serum levels of PⅠCP and PⅢNP were measured before operation and at 1, 4，7, 14, 28, 56 days after operation in all New Zealand rabbits. All indexes were measured by ELISA. After the experimental animals were executed at 56 days, pieces of myocardium in farction zone and in uninfarction zone were excised, and the deposition content of collagen I and Ⅲ were measured by

Key words: Rabbit, Creactive protein, Acute myocardial infarction, Inflammation, Metoprolol, Myocardial infarction, Collagen remodeling , Mural thrombos

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