JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Differentiation of cardiomyocytes from bone marrow mesenchymal

SONG Zhao-feng,JI Xiao-ping,WANG Xiao-rong, JIANG Shi-liang,ZHANG Xiao-fang, WAGN Rong, ZHANG Yun   

  1. Department of Cardiology, Qilu Hospital of Shandong University, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, China
  • Received:2006-02-10 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
  • Contact: SONG Zhao-feng

Abstract: To investigate the factors of differentiation of cardiomyocytes from rat mesenchymal stem cells in vitro． Methods: Mesenchymal stem cells(MSCs) were isolated from cannon born and thighbone of the rats, and were induced by 5azacytidine after culture and expansion. The proliferation and the differentiation were observed. The αactin and the cTnI were detected. Results: αactin and cTnI were found after induced by 5azacytidine. MSCs was similar to cardiomyocytes in physiology. Conclusion: MSCs can be translated to cardiaclike muscle cells after induced by 5azacytidine in vitro.

Key words: Stem cells, Cell culture, Differentiation, Rats, Wistar

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