Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (3): 71-75.doi: 10.6040/j.issn.1671-7554.0.2024.1356

• Clinical Medicine • Previous Articles    

Impact of Mycoplasma infection on pulmonary function and fractional exhaled nitric oxide in adults

ZHANG Rugang1, YIN Yue2, LI Daiyun1, DUAN Mengqi1, LIU Guilian1, WANG Ying1   

  1. 1. Department of Respiratory Medicine, the 960th Hospital of the PLA Joint Logistics Support Force, Jinan 250022, Shandong, China;
    2. Chinese PLA Medical School, Beijing 100853, China
  • Published:2025-04-08

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Abstract: Objective To investigate the effects of Mycoplasma infection on pulmonary function and fractional exhaled nitric oxide(FeNO)production in adults. Methods Based on the results of pulmonary imaging examination, a total of 94 adult patients with Mycoplasma infection were enrolled, in which 52 patients suffered from acute trachea-bronchitis(bronchitis group)and 42 patients suffered from Mycoplasma pneumoniae pneumonia(MPP group). Fifty healthy individuals who underwent physical examination during the same period were selected as a control group. The differences in pulmonary function and FeNO among the three groups were compared. Results The differences in lung function among the three groups were statistically significant(P<0.05). However, there was no statistically significant difference in FeNO among the three groups(P>0.05). Specifically, the MPP group and the control group showed statistically significant differences in forced vital capacity(FVC), forced expiratory volume in one second(FEV1), FEV1/FVC, peak expiratory flow(PEF), maximal mid-expiratory flow curve(MMEF), and the percentage of each value relative to the predicted value(%pred)(all P<0.017). The bronchitis group and the control group showed statistically significant differences in FEV1, FEV1/FVC, PEF, MMEF, and the percentage of each value relative to the predicted value(all P<0.017). The MPP group and the bronchitis group showed statistically significant differences only in FVC%pred, FEV1%pred, and MMEF%pred(all P<0.017). Conclusion All patients with Mycoplasma infection have declined lung function, with damage to both large and small airways, and predominantly obstructive ventilation function impairment. Patients with MPP have even more significant decreases in lung function, with more pronounced damage to the small airways. There is no significant difference in FeNO among the three groups.

Key words: Mycoplasma, Mycoplasma pneumoniae pneumonia, C-reactive protein, Pulmonary function, Fractional exhaled nitric oxide

CLC Number: 

  • R563.1
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