Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (3): 107-112.doi: 10.6040/j.issn.1671-7554.0.2019.1325

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Effects of inhaled allergens on pulmonary function in children with adenoid hypertrophy complicated with bronchial asthma

YANG Liping1, MU Tingting1,2, YANG Yujuan1, ZHANG Yu1, SONG Xicheng1,2   

  1. 1. Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, Shandong, China;
    2. Binzhou Medical College, Yantai 264003, Shandong, China
  • Online:2020-03-10 Published:2022-09-27

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Abstract: Objective To explore the effects of inhaled allergens on pulmonary function in children with adenoid hypertrophy complicated with bronchial asthma. Methods A total of 50 children with adenoid hypertrophy with a history of asthma treated during Dec. 2018 and May 2019 were enrolled as the study group, and another 170 children with adenoid hypertrophy but with no history of asthma served as controls. All patients received inhaled allergens serum-specific IgE test(sIgE)and pulmonary function tests at admission, and the different sensitization patterns of inhaled allergens sIgE were compared, including the percentage of forced expiratory volume in 1 second(FEV1)as a percentage of predicted value(FEV1% pre), the ratio of FEV1 to forced vital capacity(FVC)as a percentage of predicted value(FEV1/FVC% pre), maximum ventilation(MVV)as a percentage of predicted value(MVV% pre), instantaneous expiratory 山 东 大 学 学 报 (医 学 版)58卷3期 -杨丽萍,等.吸入性变应原对腺样体肥大合并支气管哮喘患儿肺功能影响 \=-flow(FEF75%%)when forced to exhale 75% of vital capacity(FEF75%% pre), instant call when forced exhalation of 50% vital capacity Airflow(FEF50%%)as a percentage of predicted value(FEF50%% pre), maximum expiratory mid-flow flow(MMEF)as a percentage of predicted value(MMEF% pre). Results There were no significant differences in gender, age, and allergen positive rate between the two groups (P>0.05). The study group had lower FEV1% pre, FEV1/FVC% pre, MVV% pre, FEF75%% pre, FEF50%% pre and MMEF% pre than the control group(t=8.219, 14.106, 5.101, 9.95, 12.006 and 10.933, respectively, all P=0.000). In the study group, 21 had positive sIgE and 29 had negative sIgE, and there were no significant differences among the positive single allergen group, positive multiple allergens group and negative allergen group(P>0.05). The FEV1% pre of lower inhaled allergens group(<3)and higher inhaled allergens group(≥3)were significantly lower than the negative inhaled allergens group(F=3.596, P=0.035). There was correlation between the inhaled allergens level and pulmonary function(FEV1% pre)in the study group(P=0.028, R2=0.568). Conclusion Inhaled allergens level is closely related to severity of pulmonary function abnormalities in children with adenoid hypertrophy and asthma. Allergen testing can preliminarily predict pulmonary function impairment and contribute to airway assessment and intervention.

Key words: Adenoid hypertrophy, Bronchial asthma, Pulmonary function, Inhaled allergen

CLC Number: 

  • R763
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