JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (3): 25-31.doi: 10.6040/j.issn.1671-7554.0.2016.1372

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Susceptibility of mesenchymal stem cells to enterovirus 71 and differential expression of miRNA

DENG Ke, LIU Yi, GAI Zhongtao   

  1. Pediatric Medical Laboratory, Qilu Childrens Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2016-10-25 Online:2017-03-10 Published:2017-03-10

Abstract: Objective To explore the functions of microRNA(miRNA)in Enterovirus 71(EV71)infection in human mesenchymal stem cells(MSCs). Mehods The EV71 infection model was established by using umbilical cord derived MSC in vitro, then the expression level of miRNAs was characterized via microarray platform and the related signaling pathways were revealed through bioinformatics analysis. Results Totally 84 differentially expressed miRNAs were found, mainly involved in the signaling pathway of the MAPK, Wnt and etc. Conclusion MSCs have a clear susceptibility to EV71, revealing that the EV71 infection can be regulated by using MAPK and Wnt signaling pathways via miRNAs.

Key words: Enterovirus 71, miRNAs, Hand, foot and mouth disease, MAPK signaling pathway

CLC Number: 

  • R574
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