JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (9): 54-57.doi: 10.6040/j.issn.1671-7554.0.2014.114

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Analysis on case characteristics and etiological changes of 414 hand-foot-mouth disease in Licheng District, Jinan, in 2010-2013

LI Min, DUAN Kun, ZHAO Ruixia   

  1. Department of Infectious Disease Control, Licheng District Center for Disease Control and Prevention, Jinan 250100, Shandong, China
  • Received:2014-03-05 Revised:2014-09-05 Online:2014-09-10 Published:2014-09-10
  • Contact: 李敏。E-mail:limin1999@sohu.com E-mail:limin1999@sohu.com

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Abstract: Objective To analyze the case characteristics and etiological changes of hand-foot-mouth disease (HFMD) in Licheng District, Jinan, in 2010-2013. Methods HFMD cases were surveyed by face-to-face method. The real-time PCR was used to detect human enterovirus nucleic acid. Results A total of 414 cases were surveyed, and children aged 1-5 years accounted for 85.99%(356/414). Male to female ratio was 1.59:1. Rash mainly distributed in hands, mouth, feet and buttocks. There were 38.89% of the cases accompanied by fever. A total of 342 specimens were tested positive, and the positive rate was 82.61%. The specimen positive rate sampling within 7 days was significantly higher than that after 7 days (84.76% vs 62.50%, χ2=12.46, P<0.001). There were statistical differences in etiology constituent in different years (χ2 =39.45, P<0.001). Conclusion HFMD mainly occurs in children aged 1-5 years in Licheng District, Jinan. Nearly 40% of the cases are with fever. The advantage pathogen types are Enterovirus 71 (EV71) and Coxasckie virus A16 (CoxA16), both alternately popular in different years. Other enteroviruses also play an important role in HFMD pathogenesis, worthy of further developing research work in the future.

Key words: Etiology, Coxasckie virus A16, Hand-foot-mouth disease, Enterovirus 71

CLC Number: 

  • R183.4
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