JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (9): 58-62.doi: 10.6040/j.issn.1671-7554.0.2014.028

Previous Articles     Next Articles

Association of serum CTRP9 and APN levels with acute coronary syndrome

LIU Tianjiao1, GUO Yuan2, LI Tingting2, ZHANG Jianning3, LI Jun1, ZHANG Peng1   

  1. 1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Department of ICU, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-01-13 Revised:2014-09-05 Online:2014-09-10 Published:2014-09-10
  • Contact: 郭媛。E-mail:guoyuan9092@163.com E-mail:guoyuan9092@163.com

PDF (PC)

136

Abstract: Objective To investigate the association of serum C1q/tumor necrosis factor related protein 9 (CTRP9) and adiponectin (APN) with acute coronary syndrome (ACS) and severity of coronary artery stenosis, and the potential mechanism. Methods A total of 61 patients with coronary heart disease(CHD) confirmed by coronary angiography (CAG) were divided into unstable angina pectoris group(UAP group, n=18), acute myocardial infarction group(AMI group, n=18), and stable angina pectoris group(SAP group, n=25). Healthy subjects without stenosis were as a control group(CON group, n=26). The UAP and AMI groups were dedined as acute coronary syndrome group (ACS group); the UAP, AMI and SAP groups were defined as coronary heart disease group(CHD goup). The serum levels of CTRP9 and APN were determined by enzyme-linked immunosorbent assay. The serum levels of lipids indexes and fasting plasma glucose(FPG)were also determined. The correlations of CTRP9 and APN with ACS and severity of coronary artery stenosis were analyzed with Pearson correlation analysis and multiple regression analysis. Results In CHD group, APN level was significantly lower than that in control group (P<0.01). In ACS group, CTRP9 level was significantly lower than those in control group (P<0.01) and SAP group (P<0.05). APN level was significantly lower than that in control group (P<0.01). In AMI group, CTRP9 level was significantly lower than that in SAP group (P<0.01). The serum CTRP9 level was positively correlated with APN (r=0.742, P<0.01) and negative correlated with FPG (r=0.592, P<0.01). CTRP9 level was only positively correlated with HDL-C level (r=0.254, P<0.05) in CHD group. Serum CTRP9 and APN levels were negatively correlated with Gensini score (r=0.579 and 0.777, P<0.01). Conclusion CTRP9 and APN are associated with ACS and the severity of coronary artery stenosis. It can provide a more convenient predictive target for the diagnosis and assessment of ACS and the severity of coronary artery disease.

Key words: C1q/tumor necrosis factor related protein 9, Coronary heart disease, Adiponectin, Acute coronary syndrome

CLC Number: 

  • R541.4
[1] Su H, Yuan Y, Wang X M, et al. Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice[J]. Basic Res Cardiol, 2013, 108(1): 1-12.
[2] 蒋婷婷, 陈星, 李婷婷, 等. 冠状动脉粥样硬化性心脏病8号染色体基因扫描[J]. 遗传, 2012, 34(8): 1043-1049. JIANG Tingting, CHEN Xing, LI Tingting, et al. Genetic scanning on chromosome 8 loci for coronary heart disease[J]. Hereditas, 2012, 34(8): 1043-1049.
[3] Kojima S, Kojima S, Maruyoshi H, et al. Hypercholes-terolemia and hypoadiponectinemia are associated with necrotic core-rich coronary plaque[J]. Int J Cardiol, 2011, 147(3): 371-376.
[4] Sawada T, Shite J, Shinke T, et al. Low plasma adi-ponectin levels are associated with presence of thin-cap fi-broatheroma in men with stable coronary artery disease[J]. Int J Cardiol, 2010, 142(3): 250-256.
[5] Iwata A, Miura S, Mori K, et al. Associations between metabolic factors and coronary plaque growth or arterial remodeling as assessed by intravascular ultrasound in patients with stable angina[J]. Hypertens Res, 2008, 31(10): 1879-1886.
[6] Li L, Cai X J, Feng M, et al. Effect of adiponectin over-expression on stability of preexisting plaques by inducing prolyl-4-hydroxylase expression[J]. Circ J, 2010, 74(3): 552-559.
[7] Margaritis M, Antonopoulos A S, Digby J, et al. Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels[J]. Circulation, 2013, 127(22): 2209-2221.
[8] Okamoto Y, Ishii S, Croce K, et al. Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques[J]. Atherosclerosis, 2012, 226(2013): 373-377.
[9] Wong G W, Krawczyk S A, Kitidis-Mitrokostas C, et al. Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin[J]. FASEB J, 2009, 23(1): 241-258.
[10] Peterson J M, Wei Z, Wong G W. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members[J]. Biochem Biophys Res Commun, 2009, 388(2): 360-365.
[11] Sun Y, Yi W, Yuan Y, et al. C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation[J]. Circulation, 2013, 128(26): 113-120.
[12] Peterson J M, Wei Z, Seldin M M, et al. CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction[J]. Am J Physiol Regul Integr Comp Physiol, 2013, 305(5): 522-533.
[13] Kambara T, Ohashi K, Shibata R, et al. CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism[J]. J Biol Chem, 2012, 287(23): 18965-18973.
[14] Uemura Y, Shibata R, Ohashi K, et al. Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell pro-liferation and neointimal formation[J]. FASEB J, 2013, 27(1): 25-33.
[15] Zheng Q, Yuan Y, Yi W, et al. C1q/TNF-related proteins, a family of novel adipokines, induce vascular re-laxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway[J]. Arterioscler Thromb Vasc Biol, 2011, 31(11): 2616-2623.
[16] Takeuchi S, Wada K, Uozumi Y, et al. Adiponectin receptor 1 expression is associated with carotid plaque stability[J]. Neurol India, 2013, 61(3): 249-253.
[1] ZHANG Yuan, LI Yang-Min, FENG Rue-Qiu, CHANG Cai-Yun, PAN Hua-Wei, WANG Shu-Mei. Relationship among serum adiponectin level, obesity and insulin resistance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 124-.
[2] WANG Chunxia, XU Yibo, YANG Ning, XIA Bing, WANG Ping, XUE Fuzhong. A prediction model for coronary heart disease risks based on health management cohort [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(6): 66-71.
[3] MA Zhenzhen, SUN Hongsheng, YANG Qingrui. Changes and clinical significance of serum adipokines in systemic lupus erythematosus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(4): 86-90.
[4] QU Qingxi, ZHAO Xin, SUN Wenyu, SONG Guangmin, MENG Xiangbin, BI Yanwen. Treatment of coronary heart diseases complicated with carotid arteriostenosis with coronary artery bypass grafting plus carotid endarterectomy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 71-74.
[5] JIANG Hongmei1,2， CHEN Wenqiang1. Clinical implication of psychotherapy on elderly patients with coronary heart failure undergoing rehabilitation [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(4): 85-88.
[6] LIU Wenhui, LI Xiaoling, YUAN Ping, LUAN Rongsheng, FENG Fei, HU Xiaoqin, YAN Jin, YANG Yanfang. Genetic polymorphisms of ADIPOQ and CAPN-10 and colorectal cancer risk [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(11): 106-112.
[7] HE Jun-feng1, LIU Jun2, WANG Wei-ren3, ZHANG Qing-feng1, YANG Qiong-fen1, LI Guang-you1， ZHOU Lin1， LI Zhi-mei1, LI Pei-zhen1 . A case-control study on the risk factors of neural tube defects in Guizhou province of China [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(7): 50-53.
[8] WANG Wen-wen1, CHEN Yu-guo2. Significance of detecting GRACE and TIMI scores for risk stratification and prognosis in patients with acute coronary syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(10): 54-57.
[9] GAO Yuan, ZHANG Hai-shan, GUO Liang, LI Yu-ze, GUAN Qi-gang, TIAN Wen, JIA Zhi-mei, JIA Da-lin, ZHANG Yue-lan, QI Guo-xian， SUN Ying-xian . Effects of administration of tirofiban and fondaparinux in acute coronary syndrome patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(06): 71-74.
[10] CHEN Wei, TAN Hong, LI Xiao-yan, YANG Yan, WEI Xiu-ying, CHEN Ying-jian, ZHANG Hong-ming. Quantity variance of endothelial progenitor cells in peripheral blood of patients
with coronary heart disease and its influence on endothelial function [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(8): 73-76.
[11] YUAN Xin, ZHENG Zhe, HU Sheng-shou. Application value of EuroSCORE in predicting readmission
after coronary artery bypass graft [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(8): 77-80.
[12] CHEN Jing1, GENG Hou-fa2, SUN Lin2. Correlation between FTO rs9939609 polymorphism and type 2 diabetes mellitus patients with coronary heart disease [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(7): 10-.
[13] ZHANG Jia-xin, MA Zhong-bing, YU Li-xiang, LIU Li-yuan, WANG Fei, GUO Ming-ming, WANG Feng, YU Zhi-gang. Associations between breast cancer and serum
levels of adiponectin and leptin [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(6): 110-.
[14] ZHU Qing1，3, KANG Wei-qiang1，2, GE Zhi-ming4, SONG Da-lin2, WANG Hai-bin2, REN Guo-rui2. Relation of glycated serum album and vulnerable plaque  characteristics in patients with CHD [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(7): 100-104.
[15] WANG Chun, GU Tianxiang, YU Yang, SONG Lai-chun, ZHANG Yu-hai, FANG Qin. Retrospective analysis of the relationship between high risk predicted by  EuroSCORE and low operative mortality in 1290 cases of OPCAB surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(7): 109-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd