JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (1): 57-61.doi: 10.6040/j.issn.1671-7554.0.2013.687

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Study on fetal malformations of cortical development by ultrasonography and magnetic resonance imaging

WANG Yin1, TAO Guo-wei1, GENG Qun1, WANG Qian2, MA Zhe1, LIU Shao-ping1, LI Yang3, PAN Qiu-li4   

  1. 1. Department of Ultrasound, Qilu Hospital of Shandong University, Jinan 250012, China;
    2. Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China;
    3. Department of Ultrasound, Second Hospital of Shandong University, Jinan 250011, China;
    4. Department of Ultrasound, Zichuan District Hospital of Zibo, Zibo 255100, Shandong, China
  • Received:2013-11-14 Online:2014-01-10 Published:2014-01-10

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Abstract:

Objective  To explore the imaging manifestations of fetal malformations of cortical development (MCD). Methods  Data of 280 singleton pregnancy women for fetal brain MRI and ultrasound examination during Aug. 2012 to Aug. 2013 were retrospectively reviewed.  Results  Altogether 12 cases were diagnosed of MCD, 8 of which were confirmed by MRI after ultrasound findings, and 4 of which were detected after being missed by ultrasound. The 8 cases included heterotopic gray matter (n=3), microcephaly (n=4), and hemimegalencephaly (n=1); the 4 cases were schizencephaly (n=2), tuberous sclerosis (n=1), and hypoplasia of temporal lobe (n=1). Among these cases, 10 terminated pregnancy, while 2 continued gestation. Conclusion  Ultrasound combined with MRI presents typical imaging characteristics, which is a powerful tool to diagnose fetal malformations of cortical development.

Key words: Malformations of cortical development, Magnetic resonance imaging, Fetus, Ultrasound

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