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山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (10): 13-19.doi: 10.6040/j.issn.1671-7554.0.2019.639

• • 上一篇    

辅助生殖治疗中卵巢过度刺激综合征的防治

石玉华,蒋琪   

  1. 山东大学附属生殖医院 国家辅助生殖与优生工程技术研究中心 生殖内分泌教育部重点实验室 山东省生殖健康临床医学研究中心, 山东 济南 250021
  • 发布日期:2022-09-27
  • 通讯作者: 石玉华. E-mail:shiyuhua2003@126.com
  • 基金资助:
    国家重点研发计划(2018YFC1003202,2017YFC1001004);泰山学者工程专项经费(ts201712103)

Prevention and treatment of ovarian hyperstimulation syndrome in assisted reproductive therapy

SHI Yuhua, JIANG Qi   

  1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics;
    The Key Laboratory of Reproductive Endocrinology(Shandong University), Ministry of Education;
    Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250100, Shandong, China
  • Published:2022-09-27

摘要: 卵巢过度刺激综合征(OHSS)是人类辅助生殖技术中最常见、复杂的医源性并发症,其病理机制目前尚不明确,普遍认为是毛细血管壁通透性增加、体液大量外渗引起的全身血流动力学改变。OHSS发生的高危因素主要包括低龄、低体质量、高雌激素水平、多囊卵巢综合征(PCOS)、OHSS既往史等。OHSS预防在于高危人群监测及合理运用促排卵药物。对中、重度 OHSS的治疗主要是对症治疗, 以减少严重并发症的发生。

关键词: 卵巢过度刺激综合征, 辅助生殖技术, 超促排卵, 防治

Abstract: Ovarian hyperstimulation syndrome(OHSS)is one of the common, complex iatrogenic complications after human assisted technology(ART). Nowadays, the pathological mechanism of OHSS is unclear. One generally accepted hypothesis is that an increase in the permeability of capillaries causes fluid leakage into the third lacuna, thus causing systematic hemodynamic change. The main risk factors of OHSS include young age, low weight, high level of estradiol(E2), polycystic ovary syndrome(PCOS), previous episodes of OHSS, and so on. The prevention of OHSS relies on the monitoring of high-risk groups and the rational use of exogenous gonadotropins. The treatment of moderate and severe OHSS is mainly symptomatic treatment to reduce the occurrence of serious complications.

Key words: Ovarian hyperstimulation syndrome, Assisted reproductive technology, Controlled ovarian hyperstimulation, Prevention and therapy

中图分类号: 

  • R711.75
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