辅助生殖技术进展

doi:10.6040/j.issn.1671-7554.0.2019.726

摘要/Abstract

摘要： 人类辅助生殖技术(ART)发展至今,已经成为治疗不孕症最有效的方法。临床上,ART除应用于治疗不孕症外,也应用于遗传病阻断及生育力保存等领域。目前,在开展ART的过程中,围绕配子和胚胎的遗传学研究、胚胎移植策略及生育力保存等研究也在如火如荼的进行,一系列的研究成果陆续发表。未来ART应用可能会涉及配子或胚胎的基因治疗、干细胞治疗等, 这些技术的安全性以及涉及的伦理社会问题也将越来越突出,需要多学科联合解决。

关键词: 辅助生殖技术, 植入前遗传学检测, 配子质量, 生育力保存, 基因治疗

Abstract: Human assisted reproductive technology(ART)has made much progress and acted as the most effective 山东大学学报 (医学版)57卷10期 -师娟子,等.辅助生殖技术进展 \=-treatment for infertility. It has also been applied to block genetic diseases and preserve fertility. In the advances of ART, studies exploring genetics of gametes and embryos, embryo transfer strategy and fertility preservation have emerged in large numbers in recent years and a series of results have been published. In the future, ART is likely to be used in gene therapy of gametes and embryos, stem cells, and so on. These new technologies will bring serious challenges to safety, ethics and society, which need to be tackled with interdisciplinary efforts.

Key words: Assisted reproductive technology, Preimplantation genetic testing, Gamete quality, Fertility preservation, Gene therapy

中图分类号:

R711.6

师娟子,陈丽娟. 辅助生殖技术进展[J]. 山东大学学报 (医学版), 2019, 57(10): 1-6.

SHI Juanzi, CHEN Lijuan. Progress in assisted reproductive technology[J]. Journal of Shandong University (Health Sciences), 2019, 57(10): 1-6.

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