山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (6): 51-56.doi: 10.6040/j.issn.1671-7554.0.2021.0296
刘萍1,2,宋玉文3,王萍4,田光伟1,郑凤杰3,吕丽3,杜娇娇3,张静2,庄向华3,陈诗鸿3
LIU Ping1,2, SONG Yuwen3, WANG Ping4, TIAN Guangwei1, ZHENG Fengjie3, LYU Li3, DU Jiaojiao3, ZHANG Jing2, ZHUANG Xianghua3, CHEN Shihong3
摘要: 目的 探讨维生素D缺乏与2型糖尿病(T2DM)合并抑郁的相关性。 方法 选取T2DM患者175例,根据抑郁自评量表(SDS)评分将患者分为抑郁组(n=74)与非抑郁组(n=101),检测血清25-羟基维生素D(25OHD)浓度,应用双能X线分析仪检测骨密度,比较两组25OHD、骨密度的差异,采用Spearman相关分析评价血清维生素D水平与SDS评分的相关性,对于单因素分析中P值较小的变量进行多因素Logistic回归分析,绘制受试者操作特征曲线(ROC)并计算曲线下面积(AUC)来评价维生素D缺乏及骨密度对于T2DM合并抑郁的诊断价值。 结果 抑郁组血清25OHD水平明显低于非抑郁组,抑郁组骨密度包括股骨颈、全髋、腰椎L1-4骨密度亦低于非抑郁组,差异有统计学意义(P<0.05);抑郁组维生素D缺乏、骨质疏松症患病率均高于非抑郁组,差异有统计学意义(P<0.05)。血清25OHD及骨密度与SDS评分呈负相关,二元Logistic回归分析结果显示维生素D缺乏(OR: 8.748,95%CI: 1.724~44.375, P=0.009)、骨质疏松症(OR: 6.385,95%CI: 2.358~17.291, P<0.001)是T2DM合并抑郁的可能影响因素。 结论 维生素D缺乏可能是T2DM合并抑郁症的危险因素,提示积极防治维生素D缺乏有助于改善T2DM患者的抑郁状态。
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