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山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (6): 51-56.doi: 10.6040/j.issn.1671-7554.0.2021.0296

• 骨质疏松症新进展专题 • 上一篇    下一篇

维生素D缺乏与2型糖尿病合并抑郁状态的相关性

刘萍1,2,宋玉文3,王萍4,田光伟1,郑凤杰3,吕丽3,杜娇娇3,张静2,庄向华3,陈诗鸿3   

  1. 1. 山东大学齐鲁医学院 山东大学第二医院, 山东 济南 250012;2. 平原县第一人民医院内分泌科, 山东 平原 253100; 3. 山东大学第二医院内分泌科, 山东 济南 250033;4. 山东大学第二医院神经内科, 山东 济南 250033
  • 发布日期:2021-06-10
  • 通讯作者: 陈诗鸿. E-mail:chenshihong26@163.com庄向华. E-mail:sd73095760653@163.com
  • 基金资助:
    国家自然科学基金(81670753,82070847,81800722);山东省重点研发计划(公益类专项)(2018GSF118108)

Correlation between vitamin D deficiency and depression in patients with type 2 diabetes mellitus

LIU Ping1,2, SONG Yuwen3, WANG Ping4, TIAN Guangwei1, ZHENG Fengjie3, LYU Li3, DU Jiaojiao3, ZHANG Jing2, ZHUANG Xianghua3, CHEN Shihong3   

  1. 1. The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Endocrinology, The First Peoples Hospital of Pingyuan, Pingyuan 253100, Shandong, China;
    3. Department of Endocrinology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China;
    4. Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong, China
  • Published:2021-06-10

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摘要： 目的 探讨维生素D缺乏与2型糖尿病(T2DM)合并抑郁的相关性。 方法 选取T2DM患者175例,根据抑郁自评量表(SDS)评分将患者分为抑郁组(n=74)与非抑郁组(n=101),检测血清25-羟基维生素D(25OHD)浓度,应用双能X线分析仪检测骨密度,比较两组25OHD、骨密度的差异,采用Spearman相关分析评价血清维生素D水平与SDS评分的相关性,对于单因素分析中P值较小的变量进行多因素Logistic回归分析,绘制受试者操作特征曲线(ROC)并计算曲线下面积(AUC)来评价维生素D缺乏及骨密度对于T2DM合并抑郁的诊断价值。 结果 抑郁组血清25OHD水平明显低于非抑郁组,抑郁组骨密度包括股骨颈、全髋、腰椎L1-4骨密度亦低于非抑郁组,差异有统计学意义(P<0.05);抑郁组维生素D缺乏、骨质疏松症患病率均高于非抑郁组,差异有统计学意义(P<0.05)。血清25OHD及骨密度与SDS评分呈负相关,二元Logistic回归分析结果显示维生素D缺乏(OR: 8.748,95%CI: 1.724~44.375, P=0.009)、骨质疏松症(OR: 6.385,95%CI: 2.358~17.291, P<0.001)是T2DM合并抑郁的可能影响因素。 结论 维生素D缺乏可能是T2DM合并抑郁症的危险因素,提示积极防治维生素D缺乏有助于改善T2DM患者的抑郁状态。

关键词: 维生素D, 抑郁, 骨质疏松症, 2型糖尿病

Abstract: Objective To investigate the correlation between vitamin D deficiency and depression in patients with type 2 diabetes mellitus(T2DM). Methods A total of 175 T2DM patients were selected and divided into the depression group(n=74)and non-depression group(n=101)according to the Self-Rating Depression Scale(SDS). Serum concentration of 25OHD was measured. Bone mineral density was measured with dual energy X-ray. The differences in 25OHD and BMD between the two groups were compared. The correlation between serum vitamin D level and SDS score was evaluated with Spearman correlation analysis. Multivariate Logistic regression analysis was performed for the variables with small P value in univariate analysis. The receiver operating characteristic curve(ROC)was drawn and the area under the curve(AUC)was calculated to evaluate the diagnostic value of vitamin D deficiency and bone mineral density in T2DM patients with depression. Results The serum level of 25OHD and bone mineral density of femoral neck, hip joint and lumbar 1-4 in the depression group were significantly lower than those in the non-depression group(P<0.05). The prevalence of vitamin D deficiency and osteoporosis in the depression group were higher than those in the non-depression group(P<0.05). Logistic regression analysis showed that vitamin D deficiency(OR: 8.748, 95%CI: 1.724-44.375, P=0.009)and osteoporosis(OR: 6.385, 95%CI: 2.358-17.291, P<0.001)were influencing factors of T2DM complicated with depression. Conclusion Vitamin D deficiency may be a risk factor of T2DM patients with depression. Active prevention and treatment of vitamin D deficiency may help improve the depressive state of T2DM patients.

Key words: Vitamin D, Depression, Osteoporosis, Type 2 diabetes mellitus

中图分类号: 

  • R587.2
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