CDKAL1(rs10946398 C/A)基因多态性与2型糖尿病易感性关系Meta分析

doi:10.6040/j.issn.1671-7554.0.2015.1143

摘要/Abstract

摘要： 目的通过Meta分析探讨细胞周期素依赖激酶5调节亚单位相关蛋白1类似物1(CDKAL1)基因rs10946398 C/A多态性位点与2型糖尿病易感性的关系。方法通过系统检索PubMed、Web of Science、CNKI、万方数据库、维普数据库等中英文数据库,纳入2007~2015年有关CDKAL1(rs10946398 C/A)基因多态性与2型糖尿病相关性的研究,以2型糖尿病组和正常对照组基因分布的OR值为统计量,应用RevMan 5.3软件对研究结果进行异质性检验和相关数据的合并,最终纳入16篇文献。结果 CDKAL1基因rs10946398 C/A多态性位点与2型糖尿病相关联,不同人种在不同遗传模型下其相关程度不同,其中等位基因遗传模型(OR: 1.58, 95% CI: 1.30~1.93)、隐形遗传模型(OR: 1.14, 95% CI: 1.09~1.20)、显性遗传模型(OR: 1.05, 95% CI: 1.01~1.09)、纯合遗传模型(OR:1.19, 95% CI: 1.13~1.26)差异均有统计学意义(P<0.01)。结论 C等位基因的风险比率显著高于A等位基因,提示CDKAL1基因rs10946398 C等位基因可能会增加人群患2型糖尿病的易感性。

关键词: Meta分析, 2型糖尿病, CDKAL1, 多态性, 易感性

Abstract: Objective To investigate the relationship between cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1(CDKAL1)gene rs10946398 C/A single neucleotide polymorphism and the susceptibility of type 2 diabetes mellitus(T2DM). Methods Databases including PubMed, Web of Science, CNKI, Wanfang, and VIP were retrieved to search for literature on the association between T2DM and CDKAL1 gene rs10946398 C/A single neucleotide polymorphism. The odds ratio of CDKAL1 gene rs10946398 C/A genotype distributions in type 2 diabetic patients compared with healthy controls were analyzed. Rev-Man 5.3 software was applied for heterogeneity test and data merge. Altogether 16 case control studies were enrolled. Results In the whole population, a significant relationship between CDKAL1 rs10946398 C/A gene polymorphism and T2DM was observed under allelic(OR: 1.58, 95% CI: 1.30-1.93), recessive(OR: 1.14, 95% CI: 1.09-1.20), dominant(OR: 1.05, 95% CI: 1.01-1.09), and homozygous(OR: 1.19, 95% CI: 1.13-1.26), all P<0.01. Conclusion CDKAL1 rs10946398 C/A gene polymorphism is significantly associated with increased T2DM risk. The C allele of the CDKAL1 rs10946398 C/A gene polymorphism may confer susceptibility to T2DM.

Key words: Meta-analysis, Polymorphism, Type 2 diabetes mellitus, Susceptibility, CDKAL1

中图分类号:

R587.1

木哈达斯·吐尔逊依明,帕它木·莫合买提,托兰古丽·买买提库尔班. CDKAL1(rs10946398 C/A)基因多态性与2型糖尿病易感性关系Meta分析[J]. 山东大学学报（医学版）, 2016, 54(2): 75-85.

Muhadasi TUERXUNYIMING, Patamu MOHEMAITI, Tuolanguli MAIMAITIKUERBAN. Association of CDKAL1 rs10946398 C/A polymorphism with type 2 diabetes[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 75-85.

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