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山东大学学报（医学版） ›› 2015, Vol. 53 ›› Issue (8): 83-86.doi: 10.6040/j.issn.1671-7554.0.2014.721

• 公共卫生与管理学 • 上一篇    下一篇

基于纵向监测队列的2型糖尿病与甲状腺结节的关联性

刘言训1, 刘佳1, 张涛1, 王璐1, 薛付忠1, 王萍2   

  1. 1. 山东大学公共卫生学院流行病与卫生统计学系;
    2. 山东大学齐鲁医院门诊手术室, 山东 济南 250012
  • 收稿日期:2014-10-17 发布日期:2015-08-10
  • 通讯作者: 刘言训.E-mail:liu-yx@sdu.edu.cn E-mail:liu-yx@sdu.edu.cn
  • 基金资助:
    山东省医药卫生科技发展计划(2013WS0230);山东省自然科学基金(ZR2013HQ056)

Type 2 diabetes mellitus associated with thyroid nodules: a longitudinal health check-up cohort study

LIU Yanxun1, LIU Jia1, ZHANG Tao1, WANG Lu1, XUE Fuzhong1, WANG Ping2   

  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Shandong University;
    2. Outpatient Operation Room, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-10-17 Published:2015-08-10

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摘要： 目的 研究2型糖尿病与甲状腺结节之间的关系,探讨影响甲状腺结节的危险因素,为预防甲状腺结节的发生提供参考.方法 构建多中心健康查体人群队列,体检者进入队列时均无甲状腺结节,共有15 528人进入随访队列,应用广义估计方程(GEE)模型研究2型糖尿病与甲状腺结节之间的关联.结果 2010年结束随访时共检出甲状腺结节患者1 592人,2型糖尿病组和健康体检组发病密度分别为36.33/1 000人年和28.55/1 000人年,两组之间差异有统计学意义(χ2=14.80, P <0.001).在控制了其他潜在的混杂因素后,多因素GEE模型发现2型糖尿病与甲状腺结节之间具有关联性(RR =1.299, P=0.001).结论 2型糖尿病是甲状腺结节的独立危险因素.

关键词: 2型糖尿病, 广义估计方程, 队列研究, 甲状腺结节

Abstract: Objective To construct a large-scale longitudinal health check-up cohort in urban Chinese population to highlight and confirm the association between type 2 diabetes mellitus and thyroid nodules, to explore the possible factors affecting the formation of thyroid nodule, and to provide guidance for the prevention of thyroid nodules. Methods A longitudinal cohort with 15 528 participants was established based on the routine health check-up systems, and generalized estimating equation (GEE) model was used to detect the association between type 2 diabetes mellitus and thyroid nodules. Results A total of 1 592 cases of thyroid nodules occurred during the 6-year follow-up. The incidence densities of type 2 diabetes mellitus group and healthy group were 36.33 per 1 000 person-years and 28.55 per 1 000 person-years respectively. The difference was statistically significant (χ2=14.80, P <0.001).Our data confirmed and clarified the association between type 2 diabetes mellitus and thyroid nodules (RR=1.299, P= 0.001) after adjusting other potential confounding factors. Conclusion Type 2 diabetes mellitus is associated with thyroid nodules in urban Chinese population.

Key words: Thyroid nodules, Longitudinal cohort study, Generalized estimated equation, Type 2 diabetes mellitus

中图分类号: 

  • R581.3
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