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山东大学学报(医学版) ›› 2017, Vol. 55 ›› Issue (6): 119-123.doi: 10.6040/j.issn.1671-7554.0.2017.338

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中性粒细胞计数与非酒精性脂肪肝关联性的前瞻性队列研究

柳晓涓1,2,蒋正1,2,康凤玲1,2,周苗1,2,林伟强1,2,薛付忠1,2   

  1. 1.山东大学公共卫生学院生物统计学系, 山东 济南 250012;2.山东大学齐鲁生物医学大数据研究中心, 山东 济南 250012
  • 收稿日期:2017-04-18 出版日期:2017-06-10 发布日期:2017-06-10
  • 通讯作者: 薛付忠. E-mail:xuefzh@sdu.edu.cn E-mail:xuefzh@sdu.edu.cn
  • 基金资助:
    国家自然科学基金(81273177);国家自然科学基金青年基金(81400072);山东省自然科学基金(2013HQ047)

Association between neutrophil count and nonalcoholic fatty liver disease:a prospective cohort study

LIU Xiaojuan1,2, JIANG Zheng1,2, KANG Fengling1,2, ZHOU Miao1,2, LIN Weiqiang1,2, XUE Fuzhong1,2   

  1. 1. Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Cheeloo Research Center for Biomedical Big Data, Shandong University, Jinan 250012, Shandong, China
  • Received:2017-04-18 Online:2017-06-10 Published:2017-06-10

摘要: 目的 探讨中性粒细胞计数与非酒精性脂肪肝(NAFLD)的关联性。 方法 基于大规模健康管理队列,针对队列基线中无NAFLD的15 463例健康体检对象随访,平均随访时间2.54年,随访结局为发生NAFLD;将基线中性粒细胞计数根据四分位数由低到高划分为4个组段(Q1、Q2、Q3、Q4);采用多元Cox回归计算中性粒细胞计数与NAFLD关联性的相对危险度(HR)。 结果 随访期间3 846人被诊断为NAFLD。Cox结果显示,以Q1为参照,在调整年龄、性别后,中性粒细胞计数的Q2、Q3、Q4三个组段的HR(95%CI)分别为1.265(1.057,1.514)、1.446(1.214,1.724)、1.605(1.350,1.907),上述基础上再调整谷丙转氨酶和γ-谷酰胺转酞酶后,Q2、Q3、Q4三个组段的HR(95%CI)分别为1.264(1.056,1.512)、1.434(1.202,1.710)、1.582(1.330,1.882),进一步调整血脂四项、空腹血糖、体质量指数(BMI)和高血压后,HR(95%CI)分别为1.181(0.986,1.415)、1.189(0.995,1.420)、1.226(1.026,1.464)。 结论 中性粒细胞计数是NAFLD发病的独立危险因素。

关键词: 中性粒细胞计数, 队列研究, Cox回归, 健康管理人群, 非酒精性脂肪肝

Abstract: Objective To explore the longitudinal association between neutrophil count and nonalcoholic fatty liver disease(NAFLD). Methods The cohort consisted of 15 463 non-NAFLD individuals at baseline who were followed for the incident of NAFLD. Cox model was applied to calculate the hazard ratio(HR)and its 95% confidence intervals(95%CI)of quantiles(Q1, Q2, Q3 and Q4)of neutrophil count predicting NAFLD. Results During the follow-up, 3 846 new cases of NAFLD occurred. With Q1 as reference group, after adjusting for age and gender, the HRs(95%CI)of Q2, Q3, and Q4 were 1.265(1.057,1.514), 1.446(1.214,1.724)and 1.605(1.350,1.907), respectively. On the basis of previous model, alanine aminotransferase and gamma glutamyltransferase were added into the model, and the HRs(95%CI)of Q2, Q3, and Q4 were 1.264(1.056,1.512), 1.434(1.202,1.710)and 1.582(1.330,1.882), respectively. After adding BMI, systolic pressure, diastolic pressure, fasting glucose and blood lipids into the model, the HRs(95%CI)were 1.181(0.986,1.415), 1.189(0.995,1.420)and 1.226(1.026,1.464), respectively. Conclusion Neutrophil count is an independent risk factor for the incidence of NAFLD.

Key words: Neutrophil count, Cox regression, Health management population, Nonalcoholic fatty liver disease, Cohort study

中图分类号: 

  • R575.5
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