子宫肌瘤与乳腺增生关联性的队列研究

doi:10.6040/j.issn.1671-7554.0.2016.249

山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (9): 53-58.doi: 10.6040/j.issn.1671-7554.0.2016.249

子宫肌瘤与乳腺增生关联性的队列研究

李向一¹,孙秀彬¹,鹿玉莲²,申振伟¹,陈亚飞¹,唐芳³,薛付忠¹

1. 山东大学公共卫生学院生物统计学系, 山东济南 250012;2. 山东大学附属济南市中心医院, 山东济南 250013;3. 山东大学附属千佛山医院健康管理中心, 山东济南 250014

收稿日期:2016-03-09 出版日期:2016-09-10 发布日期:2016-09-10
通讯作者: 薛付忠. E-mail: xuefzh@sdu.edu.cn E-mail:xuefzh@sdu.edu.cn
基金资助:
山东省科技发展计划(2014GSF118119);山东省自然科学基金(ZR2015HL102)

Relationship between uterine fibroid and hyperplasia of mammary glands: a cohort study

LI Xiangyi¹, SUN Xiubin¹, LU Yulian², SHEN Zhenwei¹, CHEN Yafei¹, TANG Fang³, XUE Fuzhong¹

1. Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
2. Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
3. Health Management Center, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China

Received:2016-03-09 Online:2016-09-10 Published:2016-09-10

摘要/Abstract

摘要： 目的基于队列设计探讨子宫肌瘤与乳腺增生的关联性。方法基于常规体检的大样本人群、纵向队列研究,终点事件为乳腺增生,采用Cox比例风险回归模型和Logistic回归模型探讨子宫肌瘤与乳腺增生的关联性。结果乳腺增生的发病密度为205.23/千人·年。未调整Cox模型显示子宫肌瘤对乳腺增生的相对危险度RR值为1.26(95%CI:1.12~1.43,P<0.001);调整年龄后,RR值变为1.37(95%CI:1.21~1.55,P<0.001);在上述模型基础上,将是否超重、饮酒、吸烟、睡眠质量等因素纳入多因素Cox模型后,RR值为1.36(95%CI:1.19~1.55,P<0.001)。Logistic回归模型显示,子宫肌瘤对乳腺增生的HR值为1.94(95%CI:1.32~2.85,P<0.001)。结论逐层加入危险因素进行调整后,子宫肌瘤与乳腺增生相关,说明子宫肌瘤患者未来发生乳腺增生的风险更大。

关键词: 子宫肌瘤, 乳腺增生, 关联性, Cox回归

Abstract: Objective To explore the association between uterine fibroid and hyperplasia of mammary glands based on a cohort design in Chinese population. Methods A longitudinal cohort based on large population was established to follow up the outcome of hyperplasia of mammary glands. Cox proportional hazards regression model and logistic model were used to detect the association between uterine fibroid and hyperplasia of mammary glands. Results The incidence density of hyperplasia of mammary glands was 205.23/1000 person-year. Unadjusted Cox model showed that relative risk(RR)value of uterine fibroids on hyperplasia of mammary glands was 1.26(95%CI: 1.12-1.43, P<0.001). Then, after adjusting age, the RR was changed to 1.37(95%CI: 1.21-1.55, P<0.001). After continually adjusting the factors of overweight, drinking, smoking, sleeping quality and other risk factors, the RR was 1.36 (95%CI: 1.19-1.55, P<0.001). Logistic model showed that HR of uterine fibroids on hyperplasia of mammary glands was 1.94(95%CI: 1.32-2.85, P<0.001). Conclusion The existence of uterine fibroids was still confirmed to be associated with hyperplasia of mammary glands after adjusting many known risk factors, suggesting that people suffering from uterine fibroids had a greater risk of hyperplasia of mammary glands.

Key words: Uterine fibroid, Association, Cox regression, Hyperplasia of mammary glands

中图分类号:

R173

李向一,孙秀彬,鹿玉莲,申振伟,陈亚飞,唐芳,薛付忠. 子宫肌瘤与乳腺增生关联性的队列研究[J]. 山东大学学报（医学版）, 2016, 54(9): 53-58.

LI Xiangyi, SUN Xiubin, LU Yulian, SHEN Zhenwei, CHEN Yafei, TANG Fang, XUE Fuzhong. Relationship between uterine fibroid and hyperplasia of mammary glands: a cohort study[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(9): 53-58.

参考文献

[1] Meisner ALW, Houman Fekrazad M, Royce ME. Breast disease: benign and malignant[J]. Medical Clinics of North America, 2008, 92(5): 1115-1141.
[2] Charles RB, Herbert W, Laube DW, et al. Obstetrics and gynecology[M]. Wolters Kluwer Health/Lippincott Williams & Wilkins, 2014: 389-392.
[3] 张健,施艳秋,任晓梅. 子宫肌瘤与乳腺增生病病因相关性研究进展[J]. 辽宁中医药大学学报, 2011, 13(1): 142-144. ZHANG Jian, SHI Yanqiu, REN Xiaomei. Progress in the study on correlation of etiology between unterine fibroids and mammary gland hyperplasia[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2011, 13(1): 142-144.
[4] 梁晓兰,杨永秀. 子宫肌瘤发病的相关危险因素Logistic回归分析[J/CD]. 中国医学前沿杂志, 2015, 7(2): 102-105. LIANG Xiaolan, YANG Yongxiu. Study on the high-risk factors for patients with uterine myoma: a Logistic regression analysis[J/CD]. Chinese Journal of Frontiers of Medical Science, 2015, 7(2): 102-105.
[5] 龙安莉. 子宫肌瘤与乳腺增生病的相关性浅析[J]. 吉林医学, 2013, 34(15): 2859-2861. LONG Anli. Analysis of causes of relevance of myoma of uterus and mammary gland hyperplasia[J]. Jilin Medical Journal, 2013, 34(15): 2859-2861.
[6] 潘秀群,陈济民. 浅述乳腺增生病与子宫肌瘤的关系[J]. 江西中医药, 2007, 38(3): 15.
[7] 张静,张宇,陶鑫焱,等. 社区子宫肌瘤妇女与乳腺疾病的关联性研究[J]. 医学信息, 2014, 27(5): 423.
[8] Zhang W, Chen Q, Yuan Z, et al. A routine biomarker-based risk prediction model for metabolic syndrome in urban Han Chinese population[J]. BMC public health, 2015, 15(1): 64.
[9] 中华预防医学会妇女保健分会乳腺保健与疾病防治学组. 乳腺增生症的诊治共识(讨论稿)[N]. 中国医学论坛报, 2013-03-18(3). http://guide.medlive.cn/guideline/5532.
[10] Greer BE, Koh WJ, Abu-Rustum N, et al. Uterine neoplasms. Clinical practice guidelines in oncology[J]. Journal of the National Comprehensive Cancer Network Jnccn, 2009, 7(5): 498-531.
[11] Kabat GC, Jones JG, Olson N, et al. A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer[J]. Cancer Causes Control, 2010, 21(6): 821-828.
[12] Socolov D, Anghelache I, Ilea C, et al. Benign breast disease and the risk of breast cancer in the next 15 years[J]. Rev Med Chir Soc Med Nat Iasi, 2015, 119(1): 135-140.
[13] Cote ML, Ruterbusch JJ, Alosh B, et al. Benign breast disease and the risk of subsequent breast cancer in African American women[J]. Cancer Prevention Research, 2012, 5(12): 1375-1380.
[14] Dorjgochoo T, Deming SL, Gao YT, et al. History of benign breast disease and risk of breast cancer among women in China: a case control study[J]. Cancer Causes Control, 2008, 19(8): 819-828.
[15] 魏来, 陈长信. 5 000例妇女乳腺疾病筛查及相关因素分析[J]. 中国妇幼保健, 2010, 25(24): 3466-3468.
[16] 余雪梅, 王静. 2930例乳腺疾病普查结果分析[J]. 现代医院, 2008,8(6): 144-145. YU Xuemei, WANG Jing. Results analysis for 2930 cases of breast disease[J]. Modern Hospital, 2008, 8(6):144-145.
[17] 徐春红. 乳腺增生病的流行病学综述[J]. 北方药学, 2013(12): 92-93.
[18] 李玉阳, 杜贾军, 刘奇, 等. 山东省61 102例妇女乳腺疾病普查报告[J]. 山东大学学报(医学版), 2011, 49(8): 157-160. LI Yuyang, DU Jiajun, LIU Qi, et al. Screening for breast diseases among 61,102 women in Shandong Province[J]. Journal of Shandong University(Health Sciences), 2011, 49(8):157-160.
[19] Jung MM, Colditz GA, Collins LC, et al. Lifetime physical activity and the incidence of proliferative benign breast disease[J]. Cancer Causes Control, 2011, 22(9): 1297-1305.
[20] Boeke CE, Tamimi RM, Berkey CS, et al. Adolescent dietary vitamin D and sun exposure in relation to benign breast disease[J]. Cancer Causes Control, 2015, 26(8): 1-7.
[21] Vessey M, Yeates D. Oral contraceptives and benign breast disease: an update of findings in a large cohort study[J]. Contraception, 2007, 76(6): 418-424.
[22] Catsburg C, Gunter MJ, Chen C, et al. Insulin, estrogen, inflammatory markers, and risk of benign proliferative breast disease[J]. Cancer Research, 2014, 74(12): 3248-3258.
[23] Su X, Boeke CE, Collins LC, et al. Intakes of fat and micronutrients between ages 13 and 18 years and the incidence of proliferative benign breast disease[J]. Cancer Causes Control, 2015, 26(1): 79-90.
[24] Liu Y, Tamimi RM, Berkey CS, et al. Intakes of alcohol and folate during adolescence and risk of proliferative benign breast disease[J]. Pediatrics, 2012, 129(5): 1192-1198.
[25] 刘聪,岳永花,郝旭亮. 乳腺增生发病机制的研究进展[J]. 医学综述, 2012, 18(5): 704-706. LIU Cong, YUE Yonghua, HAO Xuliang. Progress of research into the pathogenesis of breast hyperplasia[J]. Medical Recapitulate, 2012, 18(5): 704-706.
[26] 李程蕾, 时燕萍. 子宫肌瘤合并乳腺增生病诊治进展[J]. 中医学报, 2010, 25(1): 34-36. LI Chenglei, SHI Yanping. Hysteromyoma merger hyperplasia of mammary glands progress in diagnosis and treatment[J]. China Journal of Chinese Medicine, 2010, 25(1): 34-36.

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子宫肌瘤与乳腺增生关联性的队列研究

Relationship between uterine fibroid and hyperplasia of mammary glands: a cohort study

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