山东多中心健康管理纵向观察队列

doi:10.6040/j.issn.1671-7554.0.2017.376

摘要/Abstract

摘要： 目的介绍山东多中心健康管理纵向观察队列,描述该队列资料的主要变量和疾病的特征,阐明本队列构建的目标。方法山东多中心健康管理纵向观察队列为前瞻性、动态开放式队列。自2004年开始了数据采集、数据库构建、队列随访等一系列工作,迄今队列总人数已近100万人,最长观察时间已达12年,大约20%个体与医疗保险疾病结局数据和死因数据库实现了合并。信息收集包括问卷调查、体格检查和实验室检测。结果本次研究个体数为76 368人,男43 818人,女32 550人。高血压、糖尿病、脑卒中、冠心病的累积发病风险分别为49.40%、23.98%、4.74% 和6.82%。结论山东多中心健康管理纵向观察队列是研究各种因素在慢性病发生、发展和转归过程中的作用、构建适用于健康管理人群疾病风险评估模型的基础,基于该队列的各项研究结果能够为慢性病的健康干预提供科学依据。

关键词: 健康管理, 慢性病, 纵向观察队列, 多中心

Abstract: Objective To introduce the characteristics of diseases and main variables, and the objectives of Shandong Multi-center Longitudinal Cohort for Health Management. Methods Shandong Multi-center Longitudinal Cohort for Health Management is a prospective, dynamic and open cohort. Since 2004, we began to collect data, construct database, conduct follow-ups, and so on. So far the total number of cohort is about 100 million, the longest observation time is 12 years, and about 20% of data have merged with medical insurance disease outcome data and cause of death. The information collection methods include questionnaires, physical examinations and laboratory tests. Results A total of 76 368 people were enrolled in this study, including 43 818 males and 32 550 females. The cumulative risk of hypertension, diabetes, stroke, and coronary heart disease is 49.40%, 23.98%, 4.74% and 6.82%, respectively. Conclusion Shandong Multi-center Longitudinal Cohort for Health Management was established in order to explore the roles of various factors in the development of chronic diseases, to construct the risk assessment models, and to provide a scientific basis for interventions.

Key words: Health management, Chronic diseases, Longitudinal observation cohort, Multi-center

中图分类号:

刘娅飞,邢娉,徐秀琴,杨淑芳,刘言训,袁中尚,薛付忠. 山东多中心健康管理纵向观察队列[J]. 山东大学学报（医学版）, 2017, 55(6): 30-36.

LIU Yafei, XING Ping, XU Xiuqin, YANG Shufang, LIU Yanxun, YUAN Zhongshang, XUE Fuzhong. Shandong multi-center longitudinal cohort for health management: a brief introduction[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(6): 30-36.

参考文献

[1] Yang G, Wang Y, Zeng Y, et al. Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010[J]. Lancet, 2013, 381(9882): 1987-2015.
[2] Hafez D, Fedewa A, Moran M, et al. Workplace interventions to prevent type 2 diabetes mellitus: a narrative review[J]. Curr Diab Rep, 2017, 17(2): 9. doi: 10.1007/s11892-017-0840-0.
[3] Powers MA, Bardsley J, Cypress M, et al. Diabetes self-management education and support in type 2 diabetes[J]. Diabetes Educ, 2017, 43(1): 40-53.
[4] Paul CL, Piterman L, Shaw JE, et al. Poor uptake of an online intervention in a cluster randomised controlled trial of online diabetes education for rural general practitioners[J]. Trials, 2017, 18(1): 137. doi: 10.1186/s13063-017-1869-8.
[5] 宋艳丽, 解颖. 健康管理的研究进展[J]. 护理研究, 2009, 23(4): 1042-1043. SONG Yanli, XIE Ying. Research progress on health management[J]. Chinese Nursing Research, 2009, 23(4): 1042-1043.
[6] 卜保鹏, 黎采青, 顾庆焕, 等. 社区健康管理的模式探索[J]. 中国全科医学, 2011, 14(19): 2192- 2194. BU Baopeng, LI Caiqing, GU Qinghuan, et al. Exploring the mode of community health management[J]. Chinese General Practice, 2011, 14(19): 2192-2194.
[7] 刘瀚洋, 穆云庆. 社区在慢性病健康管理中的作用[J]. 医学与哲学, 2015, 36(23): 51-54. LIU Hanyang, MU Yunqing. The Role of community in health management for chronic diseases[J]. Medicine and Philosophy, 2015, 36(23): 51-54.
[8] 刘天鹏. 健康管理师培训教材[M]. 北京: 人民军医出版社, 2009: 5.
[9] Vartiainen E, Laatikainen T, Peltonen M, et al. Predicting coronary heart disease and stroke: The FINRISK Calculator[J]. Glob Heart, 2016, 11(2): 213-216.
[10] 詹凤羽,闫沛静,张娟,等.竞争风险模型在吸烟与缺血性脑卒中复发关系研究中的应用[J].四川大学学报(医学版),2015,46(5):736-739. ZHAN Fengyu, YAN Peijing, ZHANG Juan, et al. Determination of the association between smoking and recurrence of ischemic stroke using a competing risks model[J]. Sichuan Da Xue Xue Bao Yi Xue Ban, 2015, 46(5):736-739.
[11] Kivimäki M, Batty GD, Singhmanoux A, et al. Validating the framingham hypertension risk score results from the whitehall II study[J]. Hypertension, 2009, 54(3): 496-501.
[12] Minami M, Kobayashi Y, Toyokawa S, et al. Risk factors for new-onset atrial fibrillation during routine medical checkups of Japanese male workers[J]. Int Heart J, 2009, 50(4): 457-464.
[13] Vernet VM, Sender Palacios MJ, Jovell FE, et al. Cardiovascular risk factors: a follow up study in a non-diabetic population[J]. AtenciónPrimaria, 2010, 42(1): 15-21.
[14] 刘淼. 健康体检数据仓库的构建及相关数据挖掘[D]. 大连:大连理工大学, 2008.
[15] 张茜. 大型纵向监测健康管理队列设计及其统计分析策略研究[D]. 济南:山东大学, 2013.
[16] 鹿子龙, 唐俊利, 张高辉, 等. 山东省2013年居民高血压患病率、知晓率、治疗和控制状况分析[J]. 中华流行病学杂志, 2016, 37(9): 1207-1212. LU Zilong, TANG Junli, ZHANG Gaohui, et al. Prevalence, awareness, treatment and control of hypertension in adults in Shandong province, 2013[J]. Chin Epidemiol, 2016, 37(9): 1207-1212.
[17] 张磊, 史中锋, 迟阿鲁, 等. 居民高血压、糖尿病及知信行社区干预效果评价[J]. 中国公共卫生, 2013, 29(4): 608-611. ZHANG Lei, SHI Zhongfeng, CHI Alu, et al. Effects of 11 years' community intervention on hypertension, diabetes and KAP of the diseases among urban residents[J]. Chin J Public Health, 2013, 29(4): 608-611.
[18] 崔娟, 张吉玉, 尹修旺, 等. 宁阳县35~74岁农村居民常见慢性病患病及控制情况[J]. 中国慢性病预防与控制, 2016, 24(3): 206-208.
[19] 李昕雨, 詹丽璇, 龙隆, 等. 表观遗传调控在脑缺血中的作用[J]. 国际脑血管病杂志, 2016, 24(4): 371-377. LI Xinyu, ZHAN Lixuan, LONG Long, et al. Role of epigenetic regulation in cerebral ischemia[J].Int J Cerebrovasc Dis, 2016, 24(4): 371-377.
[20] 梁碧玉, 孔丹莉, 罗燕鸿, 等. 2型糖尿病的分子遗传学研究进展和预防策略[J]. 国际遗传学杂志, 2016, 39(6): 332-337. LIANG Biyu, KONG Danli, LUO Yanhong, et al. The research progress of molecular genetics and prevention strategy of Type 2 diabetes[J].Int J Genet Dec, 2016, 39(6): 332-337.
[21] Wang S, Zhang C, Zhang G, et al. Association between white blood cell count and non-alcoholic fatty liver disease in urban Han Chinese: a prospective cohort study[J]. BMJ Open, 2016, 6(6): e010342. doi: 10.1136/bmjopen-2015-010342
[22] 王丽晔, 吴寿岭, 杨晓利,等. 糖尿病人群中高敏C反应蛋白与新发心脑血管事件关系的前瞻性研究[J]. 中华心血管病杂志, 2011, 39(8): 749-754. WANG Liye, WU Shouling, YANG Xiaoli, et al. Association between baseline high sensitivity C-reactive protein level and the first cardio-cerebral vascular event in diabetic population: a prospective cohort study[J]. Chin J Cardiol, 2011, 39(8): 749-754.
[23] 张春风, 葛焕琦, 谢云, 等. 高敏C反应蛋白对2型糖尿病周围神经病变发病风险的影响[J]. 中华糖尿病杂志, 2016, 24(9): 787-791. ZHANG Chunfeng, GE Huanqi, XIE Yun, et al. Association between high sensitivity C reactive protein and peripheral neuropathy in patients with type 2 diabetes mellitus[J]. Chin J Diabetes, 2016, 24(9): 787-791.
[24] 王坤伟, 刘军. 白细胞与血压水平的关系[J]. 医学综述, 2015, 21(20): 3713-3715. WANG Kunwei, LIU Jun. Relationships between white blood cell count and blood pressure[J]. Medical Recapitulate, 2015, 21(20): 3713-3715.
[25] Ding L, Zhang C, Zhang G, et al. A new insight into the role of plasma fibrinogen in the development of metabolic syndrome from a prospective cohort study in urban Han Chinese population[J]. Diabetol Metab Syndr, 2015, 7(1): 110.
[26] Wu S, Lin H, Zhang C, et al. Association between erythrocyte parameters and metabolic syndrome in urban Han Chinese: a longitudinal cohort study[J]. BMC Public Health, 2013, 13(1): 989.

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