山东大学学报（医学版） ›› 2017, Vol. 55 ›› Issue (2): 4-7.doi: 10.6040/j.issn.1671-7554.0.2016.1237
柴树德
CHAI Shude
摘要： 放射性粒子植入治疗肺癌自21世纪初引入中国,临床治疗取得了令人瞩目的疗效。国内学者在引进、消化、吸收的基础上,对于其适应证、手术流程、操作方法、剂量学等问题进行了一系列深入的科学探索和创新研究。尤其是近年来模板引导、3D打印等技术的应用,使其进入了一个新的迅猛发展的阶段。本文就放射性粒子植入治疗支气管肺癌在我国开展的现状及技术创新进行了总结与分析。
中图分类号:
| [1] Nag S, Kelly JF, Horton JL, et al. Brachytherapy for carcinoma of the lung[J]. Oncology, 2001, 15(15):371-381. [2] Stewart A, Parashar B, Patel M, et al. American Brachytherapy Society consensus guidelines for thoracic brachytherapy for lung cancer[J]. Brachytherapy, 2015, 15(1): 1-11. [3] Hilaris BS, Mastoras DA. Contemporary brachytherapy approaches in non-small-cell lung cancer[J]. J Surg Oncol, 1998, 69(4):258-264. [4] Landreneau JP, Schuchert MJ, Abbas G, et al. Segmentectomy and brachytherapy mesh implantation for clinical stage I non-small cell lung cancer(NSCLC)[J]. J Surg Res, 2013, 155(2):340-346. [5] Evans AJ, Connery C, Bhora F, et al. Sublobar resection and robotic interstitial brachytherapy for early-stage non-small cell lung cancer[J]. Int J Radiat Oncol Biol Phys, 2012, 84(3):S558. [6] Fernando HC, Santos RS, Benfield JR, et al. Lobar and sublobar resection with and without brachytherapy for small stage IA non-small cell lung cancer[J]. J Thorac Cardiovasc Surg, 2005, 129(2):261-267. [7] Voynov G, Heron DE, Lin CJ, et al. Intraoperative(125)I Vicryl mesh brachytherapy after sublobar resection for high-risk stage I non-small cell lung cancer[J]. Brachytherapy, 2004, 4(4):278-285. [8] Heelan RT, Hilaris BS, Anderson LL, et al. Lung tumors:percutaneous implantation of I-125 sources with CT treatment planning[J]. Radiology, 1987, 164(3):735-740. [9] Pagola M, Vivas I, López JM. CT-guided permanent brachytherapy for patients with medically inoperable early-stage non-small cell lung cancer(NSCLC)[J]. Lung Cancer, 2008, 61(2):209-213. [10] Martínez-Monge R, Garrán C, Vivas I, et al. Percutaneous CT-guided 103Pd implantation for the medically inoperable patient with T1N0M0 non-small cell lung cancer: a case report[J]. Brachytherapy, 2004, 3(3):179-181. [11] Doyle AJ, Browne JE. Review of the guidance governing quality assurance of ultrasound systems used for guidance in prostate brachytherapy[J]. Physica Medica, 2016, 32(7):953-954. [12] 王俊杰. 影像引导组织间介入近距离治疗肿瘤概念的提出与实践[J]. 中华放射医学与防护杂志, 2014, 34(11): 801-802. [13] 王俊杰. 中国大陆地区影像引导介入近距离治疗学发展概述[J]. 中华放射肿瘤学杂志, 2016, 25(4):301-303. [14] 谢大业, 包桂霞, 林俊生, 等. 永久性125碘粒植入治疗各类癌症[J]. 中华生物医学工程杂志, 2002, 8(5): 335-336. XIE Daye, BAO Guixia, LIN Junshen. Permanent 125I seeds implantation in cancers report of 85 cases[J]. Journal of Modern Clinical Medical Bioengineering, 2002, 8(5): 335-336. [15] 申文江. 放射性粒子植入的现状与进展[J]. 中国微创外科杂志, 2007, 7(2): 118-119. [16] 王俊杰, 庄永志. 放射性粒子近距离治疗肿瘤[J]. 中国微创外科杂志, 2001, 1(3): 187-191. [17] 马旺扣, 许运龙, 邢光富, 等. 微创放射粒子植入综合治疗肺癌[J]. 中国微创外科杂志, 2003, 3(6):511-512. MA Wangkou, XU Yunlong, XING Guangfu, et al. Minimally invasive brachytherapy in the combination treatment of lung cancer[J]. Chinese Journal of Minimally Invasive Surgery, 2003, 3(6): 511-512. [18] 付改发, 雷光焰, 白新宽, 等. 微创植入125I粒子联合化疗治疗Ⅲ、Ⅳ期肺癌的初步临床应用[J]. 中国肺癌杂志, 2005, 8(6):527-529. FU Gaifa, LEI Guangyan, BAI Xinkuan, et al. A preliminary result of radioactivity 125I seed implants with micropuncture technique combined with chemotherapy in the treatment of stage Ⅲ and Ⅳ lung cancer[J]. Chinese Journal of Lung Cancer, 2005, 8(6): 527-529. [19] Yang R, Wang J, Zhang H. Dosimetric study of Cs-131, I-125, and Pd-103 seeds for permanent prostate brachytherapy[J]. Cancer Biother Radiopharm, 2009, 24(24):701-705. [20] 王俊杰, 袁慧书, 王皓, 等. CT引导下放射性125I粒子组织间植入治疗肺癌[J]. 中国微创外科杂志, 2008, 8(2):119-121. WANG Junjie, YUAN Huishu, WANG Hao, et al. CT-guided interstitial implantation of 125I seed for lung cancer[J]. Chinese Journal of Minimally Invasive Surgery, 2008, 8(2):119-121. [21] Xiang Z, Li G, Liu Z, et al. 125I Brachytherapy in locally advanced nonsmall cell lung cancer after progression of concurrent radiochemotherapy[J]. Medicine, 2015, 94(49):S73. [22] 郑广钧, 柴树德, 毛玉权, 等. 放射性125I粒子植入近距离放疗联合化疗治疗晚期肺癌的近期疗效[J]. 中国微创外科杂志, 2008, 8(2):122-124. ZHENG Guangjun, CHAI Shude, MAO Yuquan,et al. Short-term efficacy of interstitial implantation of 125I seeds combined with chemotherapy for advanced lung cancer[J]. Chinese Journal of Minimally Invasive Surgery, 2008, 8(2):122-124. [23] 柴树德, 郑广钧, 毛玉权, 等. CT引导下经皮穿刺种植放射性125I粒子治疗晚期肺癌[J]. 中华放射肿瘤学杂志, 2004, 13(4):291-293. CHAI Shude, ZHENG Guangjun, MAO Yuquan, et al. CT guided transcutaneous interstitial implantation of 125I seeds for lung carcinoma[J]. Chinese Journal of Radiation Oncology, 2004, 13(4):291-293. [24] 霍小东, 郑广钧, 柴树德, 等. CT引导下125I放射性粒子植入治疗Ⅲ期非小细胞肺癌疗效分析[J]. 中华放射医学与防护杂志, 2012, 32(2):199-203. HUO Xiaodong, ZHENG Guangjun, CHAI Shude, et al. Clinical efficacy of CT-guided 125I radioactive seeds implantation for stage Ⅲ of non-small cell lung cancer[J]. Chinese Journal of Radiological Medicine and Protection, 2012, 32(2):199-203. [25] 杨景魁, 霍小东, 闫卫亮, 等. CT引导下经皮穿刺125I粒子植入治疗非手术的早期非小细胞肺癌疗效分析[J]. 中华老年医学杂志, 2014, 33(7):757-759. YANG Jingkui, HUO Xiaodong, YAN Weiliang, et al. Effect of CT-guided 125I seeds implant brachytherapy on early non-small cell lung cancer[J]. Chinese Journal of Geriatrics, 2014, 33(7):757-759. [26] Wang ZM, Lu J, Liu T, et al. CT-guided interstitial brachytherapy of inoperable non-small cell lung cancer[J]. Lung Cancer, 2011, 74(2):253-257. [27] Li J, Yu M, Xiao Y, et al. Computed tomography fluoroscopy-guided percutaneous 125I seed implantation for safe, effective and real-time monitoring radiotherapy of inoperable stage T1-3N0M0 non-small-cell lung cancer[J]. Mol Clin Oncol, 2013, 1(6):1019-1024. [28] 霍彬, 侯朝华, 叶剑飞, 等. CT引导术中实时计划对胸部肿瘤125I粒子植入治疗的价值[J].中华放射肿瘤学杂志, 2013, 22(5):400-403. HUO Bin, HOU Zhaohua, YE Jianfei, et al. The study of intraoperative real-time planning by CT-guided in 125I seed implantation for thoracic malignance[J]. Chinese Journal of Radiation Oncology, 2013, 22(5):400-403. [29] 吉喆, 姜玉良, 郭福新, 等. 3D打印个体化非共面模板辅助放射性粒子植入治疗恶性肿瘤的剂量学验证[J]. 中华放射医学与防护杂志, 2016, 36(9):662-666. JI Zhe, JIANG Yuliang, GUO Fuxin, et al. Dosimetry verification of radioactive seed implantation for malignant tumor assisted by 3D printing individual guide template[J]. Chinese Journal of Radiological Medicine and Protection, 2016, 36(9):662-666. [30] 张颖, 林琦, 袁苑, 等. 3D打印个体化模板联合CT引导125I粒子植入治疗恶性肿瘤质量评价[J]. 山东大学学报(医学版), 2016, 54(11): 44-50. ZHANG Ying, LIN Qi, YUAN Yuan, et al. Feasibility of 3D print individual template combined with CT-guided 125I seed implantation for malignant tumors[J]. Journal of Shandong University(Health Sciences), 2016, 54(11): 44-50. |
| [1] | 黄佩文, 王旭东. 治疗非小细胞肺癌新药:靶向c-Met蛋白的抗体药物偶联物Telisotuzumab Vedotin[J]. 山东大学学报 (医学版), 2026, 64(3): 124-130. |
| [2] | 赵汉卿,周新睿,李子建,唐兴. 循环肿瘤细胞联合血清学检测在非小细胞肺癌中的应用[J]. 山东大学学报 (医学版), 2025, 63(5): 79-85. |
| [3] | 徐年兴,魏东,乔俊杰,战炳炎. CD8+、IL-6和PaO2对不可切除ⅢB/C和Ⅳ期非小细胞肺癌免疫治疗触发放射召回性肺炎的预测价值[J]. 山东大学学报 (医学版), 2025, 63(2): 29-35. |
| [4] | 山东省腔镜外科质量控制中心胸腔镜委员会. 山东省VATS/RATS非小细胞肺癌围术期质量控制指标专家共识(2025版)[J]. 山东大学学报 (医学版), 2025, 63(12): 1-5. |
| [5] | 李懿原,马珊,李爱华,龙飞. 超声支气管镜引导下碘-125粒子植入治疗肺癌中央区淋巴结转移[J]. 山东大学学报 (医学版), 2025, 63(12): 26-34. |
| [6] | 刘振昆,吕纪玲,徐伟伟,马力天,张才擎. BALF tNGS检测及培养对NSCLC合并IPFD的诊断价值[J]. 山东大学学报 (医学版), 2025, 63(11): 36-45. |
| [7] | 张荣雨,赵文,李洪欣,杨闯,王健,韩春燕,李际盛. 奥西替尼联合化疗一线治疗EGFR-RAD51融合突变转移性肺腺癌1例[J]. 山东大学学报 (医学版), 2024, 62(5): 116-120. |
| [8] | 王亚楠,梁传杰,贾梦琪,苑辉卿. 二硫键异构酶TMX1促进肺癌化疗耐药[J]. 山东大学学报 (医学版), 2023, 61(8): 31-39. |
| [9] | 王蕾,向淇,刘学伍. 伴系统性硬化症、类风湿关节炎的副肿瘤神经综合征1例[J]. 山东大学学报 (医学版), 2023, 61(7): 118-120. |
| [10] | 钟璐,薛付忠. 基于贝叶斯网络不确定性推理的肺癌风险预测模型[J]. 山东大学学报 (医学版), 2023, 61(4): 86-94. |
| [11] | 程传龙,韩闯,房启迪,刘盈,杨淑霞,崔峰,刘靖靖,李秀君. 基于时空地理加权回归模型探索肺癌发病的环境影响因素[J]. 山东大学学报 (医学版), 2023, 61(4): 95-102. |
| [12] | 杨咏青,赵鹏,汪玉,马文静,田迷迷,程亚旎,祖璐,林祥涛. 细胞外容积分数对62例不同病理类型肺癌的诊断价值[J]. 山东大学学报 (医学版), 2023, 61(2): 88-94. |
| [13] | 艾江山,高会江,艾仕文,李恒艳,石国栋,魏煜程. CT影像组学对囊腔型肺癌的诊断价值[J]. 山东大学学报 (医学版), 2023, 61(12): 70-77. |
| [14] | 韩靖,贾春玲. 肺癌患者胸外手术前治疗牙周基础疾病对预防术后肺炎发生的效果评价[J]. 山东大学学报 (医学版), 2022, 60(9): 113-118. |
| [15] | 高中霞,张铭,樊明德,谭晨阳,王梦迪,王超,樊跃飞,丁守銮,王成伟. 伽玛刀治疗81例肺癌脑转移瘤的疗效及预后因素[J]. 山东大学学报 (医学版), 2022, 60(8): 44-49. |
|
||
