通心络对自发性高血压大鼠心肌纤维化的作用

山东大学学报(医学版)

通心络对自发性高血压大鼠心肌纤维化的作用

赵学强¹,卜培莉¹，赵玉霞²，王立玲³，李传保¹，郝明秀¹，张运¹

1. 教育部和卫生部心血管重构与功能研究重点实验室山东大学齐鲁医院心内科，济南 250012；2. 山东大学齐鲁医院中医科，济南 250012； 3. 山东省立医院儿科，济南 250021

收稿日期:2007-05-15 修回日期:1900-01-01 出版日期:2007-11-24 发布日期:2007-11-24
通讯作者: 卜培莉

Effect of Tongxinluo on myocardial fibrosis of rats with spontaneous hypertension

ZHAO Xue-qiang¹,BU Pei-li¹，ZHAO Yu-xi²，WANG Li-ling³，LI Chuan-bao¹，HAO Ming-xiu¹，ZHANG Yun¹

1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital of Shandong University;2. Department of Traditional Chinese Medicine

Received:2007-05-15 Revised:1900-01-01 Online:2007-11-24 Published:2007-11-24
Contact: BU Pei-li

摘要/Abstract

摘要： 目的探讨通心络对自发性高血压大鼠心肌纤维化的作用。方法随机将16只8周龄自发性高血压大鼠(SHR)分为通心络治疗组(TXL)和空白对照组(SHR)各8只,另取8只8周龄雄性Wistar Kyoto大鼠(WKY)作为正常对照组。20周龄时超声二尖瓣口舒张早期与舒张晚期前向血流峰值速度比值(E/A)、左室瓣环处侧壁内膜下心肌舒张早期峰值速度与舒张晚期峰值速度的比值(Ea/Aa)、二尖瓣E峰减速时间(DTe)、左室等容舒张时间(IVRT)，室间隔的平均声学强度(AII1)、峰-峰强度(PPI1)及其心包校正的声学强度(CAI1)，左室后壁的平均声学强度(AII2)、峰-峰强度(PPI2)及其心包校正的声学强度 (CAI2)。结果① TXL组大鼠E/A、Ea/Aa较SHR增大(P＜0.05)，较WKY减小(P＜0.05)；TXL组大鼠DTe、IVRT较SHR缩短(P＜0.05)，较WKY延长(P＜0.05)；②　TXL组大鼠AII1、AII2、CAI1、CAI2较SHR大鼠减小(P＜0.05)，较WKY增大(P＜0.05)；TXL组大鼠PPI1、PPI2较SHR减小(P＜0.05)，较WKY增大(P＜0.05)。结论通心络可抑制压力负荷导致的心肌纤维化,改善心脏舒张功能。

关键词: 高血压 , 通心络, 大鼠, 近交SHR, 纤维化

Abstract: ObjectiveTo explore the effects of Tongxinluo on myocardial fibrosis of rats with spontaneous hypertension. Methods16 eight-week-old male rats with spontaneous hypertension (SHRs) were divided at random into two groups: the Tongxinluo group (n=8, 1.5mg·kg^-1·d^-1) and the SHR group(n=8). Another 8 eight-week-old male Wistar Kyoto rats served as the control group. 12 weeks later, the ratio of early to late mitral flow, the ratio of early to late mitral annulus velocity (E/A and Ea/Aa), the deceleration time of the E wave (DTe), the left ventricular isovolumic relaxation time (IVRT), the average image intensity (AII), the corrected acoustic intensity (CAI) and the peak to peak intensity (PPI) of the interventricular septum and the left ventricular posterior wall were all determined by cardiography. Results① The diastolic indexes E/A and Ea/Aa in the Tongxinluo group were SHR group(P＜0.05), but were significantly lower than those in the normal control group (P<0.05); the diastolic indexes DTe and IVRT in the Tongxinluo group were significantly higher than those in the SHR group (P＜0.05), but were significantly lower than those in the control group (P＜0.05). ② AII and CAI of the inter-ventricular septum and the left ventricular posterior wall in the Tongxinluo group were significantly lower than those in the SHR group, but PPI of the inter-ventricular septum and the left ventricular posterior wall was significantly higher than that in the SHR group (P＜0.05); AII and CAI of the interventricular septum and the left ventricular posterior wall in the control group were significantly lower than those in the Tongxinluo group, but PPI of the inter-ventricular septum and the left ventricular posterior wall was significantly higher than that in the Tongxinluo group (P＜0.05). Conclusion Tongxinluo capsule can reduce myocardial fibrosis caused by overload and improves the left ventricular diastolic dysfunction induced by hypertension.

Key words: Fibrosis, Rats Inbred SHR, Tongxinluo, Hypertension

中图分类号:

R541.3

赵学强,卜培莉,赵玉霞,王立玲,李传保,郝明秀,张运 . 通心络对自发性高血压大鼠心肌纤维化的作用[J]. 山东大学学报(医学版), 2007, 45(11): 1117-1121.

ZHAO Xue-qiang,BU Pei-li,ZHAO Yu-xi,WANG Li-ling,LI Chuan-bao,HAO Ming-xiu,ZHANG Yun. Effect of Tongxinluo on myocardial fibrosis of rats with spontaneous hypertension[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(11): 1117-1121.

参考文献

相关文章 15

[1]	吴逸南葛志明李方贺红姜虹张运. 自发性高血压大鼠肾脏血管紧张素转换酶2的表达[J]. 山东大学学报(医学版), 2209, 47(6): 5-.
[2]	祝林胡三元张光永丁祥就. 前列腺素E2对阻塞性黄疸大鼠小肠粘膜形态的保护作用[J]. 山东大学学报(医学版), 2209, 47(6): 12-.
[3]	孙涛张道来谢珊珊王玉卓冯玉新辛华. 酒精对原代培养的神经前体细胞间隙连接蛋白43表达的影响[J]. 山东大学学报(医学版), 2209, 47(6): 20-.
[4]	张道来孙涛谢珊珊王玉卓赵玲冯玉新辛华. 体外原代培养胎鼠大脑皮层神经元NMDAR1亚基表达的发育性变化[J]. 山东大学学报(医学版), 2209, 47(6): 28-32.
[5]	张亮,徐敏,庄向华,娄福臣,娄能俊,吕丽,郭文娟,郑凤杰,陈诗鸿. 内质网应激与凋亡在糖尿病周围神经病变中的表达变化[J]. 山东大学学报（医学版）, 2017, 55(8): 13-17.
[6]	刘芳,乔蕾,陈文超,杨丽娜. 大蒜素后处理对大鼠心肌缺血-再灌注损伤的保护作用[J]. 山东大学学报（医学版）, 2017, 55(7): 6-11.
[7]	于涛,刘焕乐,冯新,徐付印,陈亚飞,薛付忠,张成琪. 基于健康管理队列的高血压风险预测模型[J]. 山东大学学报（医学版）, 2017, 55(6): 61-65.
[8]	宋昱,毛洋,刘庆梅,乔磊,帖媛媛,鲁璐,张蕾. 通心络对兔腹主动脉粥样硬化易损斑块中三维应变的影响[J]. 山东大学学报（医学版）, 2017, 55(5): 1-7.
[9]	严芳英,单晓兰,李静媛,张杰,闫雪芳,杨奕,卜培莉. 吡格列酮通过调控Sirt3改善高血压引起的心肌纤维化机制[J]. 山东大学学报（医学版）, 2017, 55(5): 13-18.
[10]	李睿,马伟红,任满意,赵萌萌,姜珊,巨媛媛,郭颖,孙昭辉,隋树建. TWEAK与原发性高血压患者心脏重塑的相关性[J]. 山东大学学报（医学版）, 2017, 55(5): 49-55.
[11]	王维军,周宁全,王超. CT定位微创徒手穿刺软通道技术治疗中等量高血压脑出血68例[J]. 山东大学学报（医学版）, 2017, 55(5): 61-65.
[12]	张华,庄霞,刘振东,刁玉涛,杜佳晨,崔谊. 磁共振弥散张量成像技术评价高血压对年轻成年人脑白质损伤[J]. 山东大学学报（医学版）, 2017, 55(5): 56-60.
[13]	巩璐伟,周丽珍,苏国海. 培哚普利通过调节Akt-FoxO1通路保护糖尿病性心肌病大鼠心功能损伤[J]. 山东大学学报（医学版）, 2017, 55(10): 65-70.
[14]	谢海滨,武群政,刘少壮,黄鑫,程玉刚,胡三元,张光永. 肝线粒体相关内质网膜在袖状胃切除术改善糖尿病大鼠胰岛素敏感性中的作用[J]. 山东大学学报（医学版）, 2017, 55(10): 36-40.
[15]	展凤霞,丁娟,马蓓蕾,王谦. 雌二醇对Th1细胞极化与肝纤维化形成的影响[J]. 山东大学学报（医学版）, 2016, 54(8): 64-68.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed