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山东大学学报（医学版） ›› 2017, Vol. 55 ›› Issue (5): 49-55.doi: 10.6040/j.issn.1671-7554.0.2017.125

• 临床医学 • 上一篇    下一篇

TWEAK与原发性高血压患者心脏重塑的相关性

李睿1,马伟红1,任满意2,赵萌萌1,姜珊1,巨媛媛1,郭颖1,孙昭辉1,隋树建1   

  1. 1.山东大学第二医院心脏内科, 山东 济南 250033;2.山东大学附属千佛山医院心内科, 山东 济南 250014
  • 收稿日期:2017-02-09 出版日期:2017-05-10 发布日期:2017-05-10
  • 通讯作者: 隋树建. E-mail:suisj@163.com E-mail:suisj@163.com
  • 基金资助:
    山东省科技攻关项目(2013GSF12110)

Correlation between TWEAK and cardiac remodeling in essential hypertensive patients

LI Rui1, MA Weihong1, REN Manyi2, ZHAO Mengmeng1, JIANG Shan1, JU Yuanyuan1, GUO Ying1, SUN Zhaohui1, SUI Shujian1   

  1. 1. Department of Cardiology, Second Hospital of Shandong University, Jinan 250033, Shandong, China;
    2. Department of Cardiology, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2017-02-09 Online:2017-05-10 Published:2017-05-10

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摘要： 目的 探究肿瘤坏死因子样凋亡微弱诱导剂(TWEAK)与原发性高血压患者心脏重塑的关系。 方法 选取原发性高血压5年以上患者88例为高血压组,检测血清TWEAK水平并分为高表达组(n=51)和低表达组(n=37);选取同期健康体检者20例为对照组。采用RT-PCR 法检测入选者外周血单个核细胞(PBMCs)中TWEAK mRNA表达量,采用ELISA法检测血清中可溶性TWEAK(sTWEAK)和基质金属蛋白酶1(sMMP-1)表达水平;超声心动图测量左心房直径(LAD)、左心房容积(LAV)、左心房容积指数(LAVI)、二尖瓣血流频谱舒张早期波E峰(E)、二尖瓣血流频谱心房收缩波A峰(A)、二尖瓣环舒张早期与心房收缩期峰值运动速度比(E/A),二尖瓣环侧壁运动频谱峰值比值(E/E')。 结果 高表达组和低表达组sTWEAK、TWEAK mRNA、sMMP-1水平均高于对照组(P<0.05),且高表达组显著高于低表达组(P<0.01);高表达组和低表达组LAVI、E/E'均高于对照组(P<0.05),且高表达组显著高于低表达组(P<0.01);sTWEAK、TWEAK mRNA与sMMP-1、LAVI、E/E'呈显著正相关性(P<0.01)。 结论 高血压患者心脏重塑可能与TWEAK高表达有关。

关键词: 原发性高血压, 肿瘤坏死因子样凋亡微弱诱导物, 基质金属蛋白酶1, 心脏重塑

Abstract: Objective To investigate the association between tumor necrosis factor-like weak inducer of apoptosis(TWEAK)and cardiac remodeling in essential hypertensive patients. Methods A total of 88 hypertensive patients enrolled as the hypertension group were divided into two subgroups according to the serum level of soluble TWEAK(sTWEAK): high sTWEAK group(n=51)and low sTWEAK group(n=37). Another 20 healthy subjects served as the control group. The mRNA expression of TWEAK in peripheral blood mononuclear cells(PBMCs)was detected using real-time PCR(RT-PCR). sTWEAK and matrix metalloproteinase 1(sMMP-1)were measured with enzyme linked immunosorbent assay(ELISA). The left atrium diameter(LAD), left atrial volume(LAV), left atrial volume index(LAVI), early wave of mitral flow(E), atrial wave of mitral flow(A), ratio of mitral flow early wave to atrial wave(E/A), and ratio of mitral flow early wave to mitral annular early diastolic velocity(E/E')of mitral valve ring were measured with echocardiography. Results The levels of sTWEAK, TWEAK mRNA and sMMP-1 were higher in 山 东 大 学 学 报 (医 学 版)55卷5期 -李睿,等.TWEAK与原发性高血压患者心脏重塑的相关性 \=-the hypertension group than in the control group(P<0.05), These indexes were significantly greater in the high sTWEAK group than in the low sTWEAK group(P<0.01). LAVI and E/E' were greater in the hypertension group than in the control group(P<0.05), and were significantly greater in the high sTWEAK group than in the low sTWEAK group(P<0.01). Furthermore, the sTWEAK and TWEAK mRNA showed a significant positive correlation with sMMP-1, LAVI and E/E'(P<0.01). Conclusion Cardiac remodeling in essential hypertensive patients might be correlated with up-regulated TWEAK.

Key words: Essential hypertension, Tumor necrosis factor-like weak inducer of apoptosis, Matrix metalloproteinase 1, cardiac remodeling

中图分类号: 

  • R542.2
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