铁死亡在腹主动脉瘤中的研究进展

doi:10.6040/j.issn.1671-7554.0.2024.0496

摘要/Abstract

摘要： 腹主动脉瘤在高龄人群中发病率高、破裂风险大,是血管外科常见的危重急症,然而目前还缺少腹主动脉瘤有效的治疗药物或靶点。铁死亡是近几年新发现的一种可调控的细胞死亡方式,特点是依赖于铁离子和脂质过氧化物堆积。铁死亡广泛参与了心血管、肿瘤、神经系统等多种疾病的发生发展,本文回顾近5年铁死亡与腹主动脉瘤的相关研究进展,总结铁死亡的主要机制及其在腹主动脉瘤中的作用,发现铁死亡可能通过影响血管平滑肌细胞的衰老、死亡和表型转换等来参与腹主动脉瘤的进展,提出铁死亡有望成为腹主动脉瘤防治的新靶点。

关键词: 铁死亡, 腹主动脉瘤, 血管平滑肌细胞, 氧化

Abstract: Abdominal aortic aneurysm is a common critical emergency in vascular surgery with a high incidence and a high risk of rupture in the elderly population. However, there is still a lack of effective therapeutic drugs or targets for abdominal aortic aneurysm. Ferroptosis is a newly discovered regulated cell death mode in recent years, characterized by its dependence on the accumulation of iron ions and lipid peroxides. Ferroptosis is widely involved in the development of cardiovascular, neoplastic, neurological and other diseases. This article summarizes the main mechanism of ferroptosis and its role in abdominal aortic aneurysm by reviewing the progress of research related to ferroptosis and abdominal aortic aneurysm in the past five years. Ferroptosis may be involved in the progression of abdominal aortic aneurysm by affecting the senescence, death and phenotype transition of vascular smooth muscle cells, suggesting that ferroptosis may be a new target for the prevention and treatment of abdominal aortic aneurysm.

Key words: Ferroptosis, Abdominal aortic aneurysm, Vascular smooth muscle cell, Oxidation

中图分类号:

R543.1

牛帅,吴学君. 铁死亡在腹主动脉瘤中的研究进展[J]. 山东大学学报 (医学版), 2024, 62(9): 74-79.

NIU Shuai, WU Xuejun. Research progress of ferroptosis in abdominal aortic aneurysm[J]. Journal of Shandong University (Health Sciences), 2024, 62(9): 74-79.

参考文献

[1] 中华医学会外科学分会血管外科学组. 腹主动脉瘤诊断和治疗中国专家共识(2022版)[J]. 中国实用外科杂志, 2022, 42(4): 380-387. Society for Vascular Surgery, Chinese Society of Surgery, Chinese Medical Association. Chinese expert consensus on the diagnosis and treatment of abdominal aortic aneurysm(2022 edition)[J]. Chinese Journal of Practical Surgery, 2022, 42(4): 380-387.
[2] 种振岳, 王默, 高斌斌, 等. 腹主动脉瘤破裂的外科急救(附19例报告)[J]. 山东大学学报(医学版), 2010, 48(8): 111-112, 116. ZHONG Zhenyue, WANG Mo, GAO Binbin, et al. Experience of emergency surgery on ruptured abdominal aortic aneurysm(a report of 19 cases)[J]. Journal of Shandong University(Health Sciences), 2010, 48(8): 111-112, 116.
[3] Lu HC, Du W, Ren L, et al. Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms[J]. J Am Heart Assoc, 2021, 10(24): e023601. doi:10.1161/JAHA.121.023601.
[4] Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018[J]. Cell Death Differ, 2018, 25(3): 486-541.
[5] Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149(5): 1060-1072.
[6] Wu XG, Li Y, Zhang SC, et al. Ferroptosis as a novel therapeutic target for cardiovascular disease[J]. Theranostics, 2021, 11(7): 3052-3059.
[7] Chen X, Kang R, Kroemer G, et al. Broadening horizons: the role of ferroptosis in cancer[J]. Nat Rev Clin Oncol, 2021, 18(5): 280-296.
[8] Ding XS, Gao L, Han Z, et al. Ferroptosis in Parkinsons disease: molecular mechanisms and therapeutic potential[J]. Ageing Res Rev, 2023, 91: 102077. doi:10.1016/j.arr.2023.102077.
[9] Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease[J]. Cell, 2017, 171(2): 273-285.
[10] Feng HZ, Stockwell BR. Unsolved mysteries: how does lipid peroxidation cause ferroptosis?[J]. PLoS Biol, 2018, 16(5): e2006203. doi:10.1371/journal.pbio.2006203.
[11] Jiang L, Kon N, Li TY, et al. Ferroptosis as a p53-mediated activity during tumour suppression[J]. Nature, 2015, 520(7545): 57-62.
[12] Conrad M, Proneth B. Selenium: tracing another essential element of ferroptotic cell death[J]. Cell Chem Biol, 2020, 27(4): 409-419.
[13] Doll S, Freitas FP, Shah R, et al. FSP1 is a glutathione-independent ferroptosis suppressor[J]. Nature, 2019, 575(7784): 693-698.
[14] Bersuker K, Hendricks JM, Li ZP, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis[J]. Nature, 2019, 575(7784): 688-692.
[15] Soula M, Weber RA, Zilka O, et al. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers[J]. Nat Chem Biol, 2020, 16(12): 1351-1360.
[16] Kraft VAN, Bezjian CT, Pfeiffer S, et al. GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling[J]. ACS Cent Sci, 2020, 6(1): 41-53.
[17] Yin HY, Xu LB, Porter NA. Free radical lipid peroxidation: mechanisms and analysis[J]. Chem Rev, 2011, 111(10): 5944-5972.
[18] Conrad M, Pratt DA. The chemical basis of ferroptosis[J]. Nat Chem Biol, 2019, 15(12): 1137-1147.
[19] Kagan VE, Mao GW, Qu F, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis[J]. Nat Chem Biol, 2017, 13(1): 81-90.
[20] Gao MH, Monian P, Pan QH, et al. Ferroptosis is an autophagic cell death process[J]. Cell Res, 2016, 26(9): 1021-1032.
[21] Jelinek A, Heyder L, Daude M, et al. Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis[J]. Free Radic Biol Med, 2018, 117: 45-57. doi:10.1016/j.free-radbiomed.2018.01.019.
[22] Lee H, Zandkarimi F, Zhang YL, et al. Energy-stress-mediated AMPK activation inhibits ferroptosis[J]. Nat Cell Biol, 2020, 22(2): 225-234.
[23] Gao MH, Monian P, Quadri N, et al. Glutaminolysis and transferrin regulate ferroptosis[J]. Mol Cell, 2015, 59(2): 298-308.
[24] Shin D, Lee J, You JH, et al. Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer[J]. Redox Biol, 2020, 30: 101418. doi:10.1016/j.redox.2019.101418.
[25] Sawada H, Hao H, Naito Y, et al. Aortic iron overload with oxidative stress and inflammation in human and murine abdominal aortic aneurysm[J]. Arterioscler Thromb Vasc Biol, 2015, 35(6): 1507-1514.
[26] Delbosc S, Diallo D, Dejouvencel T, et al. Impaired high-density lipoprotein anti-oxidant capacity in human abdominal aortic aneurysm[J]. Cardiovasc Res, 2013, 100(2): 307-315.
[27] Sun DY, Wu WB, Wu JJ, et al. Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence[J]. Nat Commun, 2024, 15(1): 1429. doi:10.1038/S41467-024-45823-w.
[28] Schoenmakers E, Marelli F, Jørgensen HF, et al. Selenoprotein deficiency disorder predisposes to aortic aneurysm formation[J]. Nat Commun, 2023, 14(1): 7994. doi:10.1038/S41467-023-43851-6.
[29] Colie S, Pecher C, Girolami JP, et al. Modulation by bradykinin and nitric oxide of angiotensin II-induced apoptosis in a vascular smooth muscle cell phenotype[J]. Int Immunopharmacol, 2008, 8(2): 231-236.
[30] Ji QX, Zeng FY, Zhou J, et al. Ferroptotic stress facilitates smooth muscle cell dedifferentiation in arterial remodelling by disrupting mitochondrial homeostasis[J]. Cell Death Differ, 2023, 30(2): 457-474.
[31] Zhang SC, Bei YR, Huang YL, et al. Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice[J]. Mol Med, 2022, 28(1): 121. doi:10.1186/S10020-022-00549-7.
[32] Chen Y, Yi X, Huo B, et al. BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection[J]. Pharmacol Res, 2022, 177: 106122. doi:10.1016/j.phrs.2022.106122.
[33] Bai T, Li MX, Liu YF, et al. Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell[J]. Free Radic Biol Med, 2020, 160: 92-102. doi: 10.1016/j.freeradbiomed.2020.07.026.
[34] Li L, Wang HN, Zhang J, et al. Effect of endothelial progenitor cell-derived extracellular vesicles on endothelial cell ferroptosis and atherosclerotic vascular endothelial injury[J]. Cell Death Discov, 2021, 7(1): 235. doi:10.1038/S41420-021-00610-0.
[35] Wu ZN, Chen TW, Qian YX, et al. High-dose ionizing radiation accelerates atherosclerotic plaque progression by regulating P38/NCOA4-mediated ferritinophagy/ferroptosis of endothelial cells[J]. Int J Radiat Oncol Biol Phys, 2023, 117(1): 223-236.
[36] Ma HT, Huang YT, Tian WR, et al. Endothelial transferrin receptor 1 contributes to thrombogenesis through cascade ferroptosis[J]. Redox Biol, 2024, 70: 103041. doi:10.1016/j.redox.2024.103041.
[37] He X, Xiong YC, Liu Y, et al. Ferrostatin-1 inhibits ferroptosis of vascular smooth muscle cells and alleviates abdominal aortic aneurysm formation through activating the SLC7A11/GPX4 axis[J]. FASEB J, 2024, 38(2): e23401. doi:10.1096/fj.202300198RRR.

相关文章 15

[1]	鹿向东杨伟徐广明曲元明. 脑膜瘤中PPAR-γ的表达及曲格列酮对脑膜瘤培养细胞生长的影响[J]. 山东大学学报(医学版), 2209, 47(6): 65-.
[2]	卫任,郭伟. 腹主动脉瘤腔内治疗现状[J]. 山东大学学报 (医学版), 2024, 62(9): 13-18.
[3]	史潇兮,辛世杰. 腹主动脉瘤的开放手术[J]. 山东大学学报 (医学版), 2024, 62(9): 26-29.
[4]	霍正坤,孔祥骞,吴学君. 感染性主动脉瘤诊疗进展[J]. 山东大学学报 (医学版), 2024, 62(9): 42-48.
[5]	周永康,孙境,张帅,钱向阳. 胸腹主动脉瘤开放修复脊髓保护策略的研究进展[J]. 山东大学学报 (医学版), 2024, 62(9): 49-54.
[6]	范立彬,张鸿坤. 腹主动脉瘤腔内修复术后Ⅱ型内漏的预防及治疗进展[J]. 山东大学学报 (医学版), 2024, 62(9): 55-60.
[7]	孙丛丛,崔文静,张锦涛,张东,刘晓菲,潘云,亓倩,徐嘉蔚,曾荣,郭红喜,董亮. 铁死亡在支气管哮喘气道重塑中的作用[J]. 山东大学学报 (医学版), 2024, 62(7): 1-9.
[8]	刘海霞,皇甫莎莎,桑晓玉,崔东清,毕建忠,王萍. 间充质干细胞对实验性自身免疫性脑脊髓炎小鼠铁死亡的影响[J]. 山东大学学报 (医学版), 2024, 62(6): 1-8.
[9]	林雨洋,王蓓,李菲. 大于10 mm甲状腺乳头状癌侧颈区淋巴结转移预测[J]. 山东大学学报 (医学版), 2024, 62(6): 54-64.
[10]	沈海涛,乔亚琴,董萍,路燕. Toll样受体4调控的程序性坏死和铁死亡对对乙酰氨基酚肝损伤的影响[J]. 山东大学学报 (医学版), 2024, 62(4): 1-8.
[11]	赵智博,满振涛,李伟. 胆固醇代谢在骨关节炎疾病中的作用及研究进展[J]. 山东大学学报 (医学版), 2024, 62(2): 1-9.
[12]	扈艳雯,赵蕙琛,马小莉,刘元涛,张玉超. GLP-1通过细胞色素P450表氧化酶途径抑制氧化应激[J]. 山东大学学报 (医学版), 2023, 61(8): 10-16.
[13]	闫丛丛,陈辰,谢倩,王亚楠,张鑫璐,张迎春,武斌. 双酚A暴露对KGN细胞m6A修饰水平的影响[J]. 山东大学学报 (医学版), 2023, 61(8): 17-23.
[14]	刘洋,陈贵海. 寒痉汤对冷刺激诱导主动脉平滑肌细胞氧化应激的影响及机制[J]. 山东大学学报 (医学版), 2023, 61(8): 24-30.
[15]	祁少俊,唐延金,张正铎,吴虹,张佳程,秦川,刘锐,高希宝. 补充多种微量元素对高糖饮食大鼠的保护作用[J]. 山东大学学报 (医学版), 2023, 61(7): 19-26.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed