山东大学学报 (医学版) ›› 2024, Vol. 62 ›› Issue (2): 1-9.doi: 10.6040/j.issn.1671-7554.0.2024.0045
• 专家综述 •
赵智博1,2,满振涛2,李伟1,2
ZHAO Zhibo1,2, MAN Zhentao2, LI Wei1,2
摘要： 骨关节炎(osteoarthritis, OA)是一种与年龄相关的退行性疾病,长期以来一直与肥胖有关。有研究指出OA 可能是一种代谢性疾病,因为它不仅累及负重关节也累及非负重关节。新出现的证据表明OA中存在着异常的胆固醇代谢。异常的胆固醇代谢途径会伴随着产生一些促炎物质,这些物质对OA的发展至关重要。因此调节胆固醇异常代谢的药物可能在OA中具有巨大的治疗前景。现着重总结了胆固醇代谢在OA疾病中的作用和综合分子机制,提出多角度调控胆固醇代谢可能是临床治疗OA疾病的一种有前景的策略。
中图分类号:
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