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山东大学学报（医学版） ›› 2015, Vol. 53 ›› Issue (6): 94-96.doi: 10.6040/j.issn.1671-7554.0.2014.454

• 临床医学 • 上一篇    

尿液中C2C水平对膝关节骨关节炎的诊断价值

辛林伟, 王梨明, 李朝旭, 唐际存, 江梦谣, 区权利   

  1. 桂林医学院附属医院创伤手外科, 广西 桂林 541001
  • 收稿日期:2014-07-10 修回日期:2015-02-28 发布日期:2015-06-10
  • 通讯作者: 辛林伟。 E-mail:xinlinwei@hotmail.com E-mail:xinlinwei@hotmail.com
  • 基金资助:
    广西桂林市科学研究与技术开发计划(30130120-5)

Significance of type Ⅱ collagen biomarker C2C in the diagnosis of knee osteoarthritis

XIN Linwei, WANG Liming, LI Chaoxu, TANG Jicun, JIANG Mengyao, QU Quanli   

  1. Department of Orthopaedics, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi, China
  • Received:2014-07-10 Revised:2015-02-28 Published:2015-06-10

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摘要： 目的 探讨尿液中C2C水平与膝关节骨关节炎(KOA)患者病变程度的关系。方法 收集90例KOA患者(KOA组)和20例非KOA患者(正常对照组)的尿液标本及膝关节正侧位影像学资料,采用Kellgren-Lawrence放射学分级标准对KOA组的影像学表现进行分级:Ⅰ级组、Ⅱ级组、Ⅲ级组和Ⅳ级组。采用酶联免疫吸附试验(ELISA)检测尿液中C2C水平。结果 KOA组尿液中C2C水平高于正常对照组(P < 0.001)。C2C水平Ⅳ组 > Ⅲ组 > Ⅱ组 > Ⅰ组和正常对照组(P=0.000)。结论 C2C升高水平与KOA的影像学分级平行, 两者呈高度正相关性。C2C可作为区分KOA严重程度的标志物,也可作为评价药物及手术治疗KOA疗效的参考指标,但其作为早期诊断的价值有限。

关键词: Ⅱ型胶原, 膝关节骨关节炎, 软骨代谢产物, C2C, 尿液

Abstract: Objective To discuss the association between the level of type Ⅱ collagen biomarker C2C in urine and severity of knee osteoarthritis (KOA). Methods Urine samples and anteroposterior and lateral films of knee joint of 90 KOA patients (KOA group) and 20 healthy controls (control group) were collected and compared. According to Kellgren-Lawrence radiographic grading criteria, patients in the KOA group were divided into grade Ⅰ, Ⅱ, Ⅲ, and Ⅳ subgroups. Urine C2C level was detected with enzyme-linked immunosorbent assay (ELISA). Results Urine C2C level in KOA group was significantly higher than that in control group (P<0.01). In the subgroups, the C2C level in subgroup Ⅳ was the highest, followed by subgroup Ⅲ, Ⅱ and Ⅰ (P=0.000). The C2C level in subgroup I was similar to that in control group, with no significant difference (P>0.05). Conclusion The urine C2C level may serve as an indicator for the progression and curative effect of KOA, rather than an index for the early diagnosis of KOA.

Key words: C2C, Urine, Cartilage metabolites, Knee osteoarthritis, Type Ⅱcollagen

中图分类号: 

  • R684.3
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