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山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (8): 32-37.doi: 10.6040/j.issn.1671-7554.0.2021.0877

• 生殖免疫的基础与临床研究进展专题 • 上一篇    下一篇

免疫治疗在胚胎反复种植失败中的应用进展

邓晓惠1,2,*(),郭玲1,2   

  1. 1. 山东大学齐鲁医院妇产科生殖医学中心,山东 济南 250012
    2. 山东大学齐鲁医学院,山东 济南 250012
  • 收稿日期:2021-07-29 出版日期:2021-08-10 发布日期:2021-09-16
  • 通讯作者: 邓晓惠 E-mail:dxh@sdu.edu.cn
  • 作者简介:邓晓惠, 主任医师,博士研究生导师。现任山东大学齐鲁医院妇儿中心副主任、不孕不育诊疗中心主任,山东省医学会生殖医学分会副主任委员、山东免疫学会生殖免疫专业委员会主任委员、山东省妇幼保健协会生育保健分会副主任委员、山东省医学伦理学学会生殖医学伦理学分会副主任委员、中国医师协会生育力保存专业委员会委员,国家辅助生殖技术管理专家库成员。主编《生殖医学技术及其彩色图谱》《体外受精与胚胎移植》等医学视听教材。临床工作与研究方向:生殖内分泌、辅助生育技术、肿瘤患者生育力保存、绝经期保健及治疗等

Applications and progress of immunotherapy in repeated implantation failure

Xiaohui DENG1,2,*(),Ling GUO1,2   

  1. 1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
    2. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2021-07-29 Online:2021-08-10 Published:2021-09-16
  • Contact: Xiaohui DENG E-mail:dxh@sdu.edu.cn

摘要:

胚胎反复种植失败(RIF)是现代生殖医学领域研究的热点和难点问题,其发病因素繁多且复杂。随着生殖免疫学的不断兴起,近年来研究发现,免疫因素在胚胎种植过程中发挥重要作用,有针对性的免疫治疗方法可改善部分患者的妊娠结局。本文主要从RIF免疫因素的发病机制及相关免疫治疗方法的应用进展等方面进行综述,以期为未来的基础研究和临床治疗提供参考。

关键词: 体外受精-胚胎移植, 反复种植失败, 免疫治疗

Abstract:

Repeated implantation failure (RIF) is a hot and difficult issue in the field of modern reproductive medicine, with numerous and complex pathogenic factors. With the rise of reproductive immunology, recent studies have found that immune factors play an important role in the process of embryo implantation, and targeted immunotherapy can improve the pregnancy outcome of some patients. This article reviews the pathogenesis of RIF immune factors and the progress in the application of related immunotherapy methods, hoping to provide references for future basic research and clinical treatment.

Key words: In vitro fertilization-embryo transfer, Repeated implantation failure, Immunotherapy

中图分类号: 

  • R392.69
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