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山东大学学报 (医学版) ›› 2020, Vol. 58 ›› Issue (5): 62-68.doi: 10.6040/j.issn.1671-7554.0.2019.1439

• • 上一篇    

腔内理疗对89例薄型子宫内膜冻融胚胎移植患者妊娠结局的影响

张秀清1,2,张敬2,蒋琪2,李晨2,刘畅2,李瑞静2,冯惠娟3,耿玲1   

  1. 1. 山东大学附属省立医院, 山东 济南 250021;2. 山东大学附属生殖医院健康管理部, 山东 济南 250021;3. 山东大学附属生殖医院病友服务中心, 山东 济南 250021
  • 发布日期:2022-09-27
  • 通讯作者: 耿玲. E-mail:gengling@sduivf.com
  • 基金资助:
    山东省医药卫生科技发展计划(2016WS0367)

Effect of intracavitary physiotherapy on pregnancy outcomes of 89 patients with thin endometrium in frozen-thawed embryo transfer cycles

ZHANG Xiuqing1,2, ZHANG Jing2, JIANG Qi2, LI Chen2, LIU Chang2, LI Ruijing2, FENG Huijuan3, GENG Ling1   

  1. 1. Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Health Management Department, Reproductive Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    3. Patient Service Center, Reproductive Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Published:2022-09-27

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摘要： 目的 探讨腔内理疗对薄型子宫内膜患者冻融胚胎移植周期妊娠结局的影响。 方法 回顾性分析2017年1 月至2018年6月期间在山东大学附属生殖医院至少连续两次因子宫内膜<8 mm放弃冻胚移植的186例患者,再次准备冻融胚胎移植前利用盆腔治疗仪行腔内理疗者89例为实验组,同等条件非腔内理疗者97例为对照组;同时根据年龄将患者分为A组(24~34岁)和B组(35~42岁)两个年龄亚组,所有患者均移植1枚优质囊胚,比较两亚组内实验组与对照组患者移植周期子宫内膜厚度、子宫内膜穿支血流分级、生化妊娠率、生化妊娠流产率、临床妊娠率、临床妊娠流产率及活产率。 结果 年龄亚组内实验组与对照组患者移植前的子宫内膜厚度差异无统计学意义［(A组:(0.74±0.11)mm vs(0.76±0.10)mm,P=0.422;B组:(0.73±0.11)mm vs(0.73±0.10)mm,P=0.854)］,子宫内膜穿支血流分级差异无统计学意义［(A组:P=0.697,B组:P=0.835)。A组中腔内理疗组与对照组相比,其生化妊娠率(65.5% vs 50.0%,P=0.103)及临床妊娠率(51.7% vs 46.0%,P=0.553)、活产率(37.9% vs 40.0%,P=0.826)差异均无统计学意义,但B组中腔内理疗组与对照组相比,其生化妊娠率(64.5% vs 38.3%, P=0.023)、临床妊娠率(61.3% vs 25.5%, P=0.002)及活产率(45.2% vs 21.3%, P=0.025)均显著提高,生化妊娠流产率降低(5.0% vs 33.3%,P=0.038),差异有统计学意义。 结论 对于高龄(35~42岁)薄型子宫内膜患者,冻胚移植前行腔内理疗可显著改善妊娠结局。

关键词: 腔内理疗, 薄型子宫内膜, 冻融胚胎移植, 妊娠结局

Abstract: Objective To explore the effect of intracavitary physiotherapy on the pregnancy outcomes of patients with thin endometrium(TE)in frozen-thawed embryo transfer cycles. Methods Clinical data of 186 patients who underwent assisted reproduction technology(ART)but cancelled the frozen-thawed embryo transfer cycles at least twice due to endometrial thickness <8 mm during Jan. 2017 and Jun. 2018 were retrospectively analyzed. Those who were going to receive intracavitary physiotherapy during their new frozen-thawed embryo transfer cycles were enrolled into the treatment group(n=89), and the others who would not receive intracavitary physiotherapy were enrolled into the control group(n=97). According to the age, the patients were divided into group A(24-34 years old)and group B(35-42 years old). All patients received a high-quality blastocyst transfer in their new frozen-thawed embryo transfer cycles. The endometrial thickness, endometrial blood flow, biochemical pregnancy rate, biochemical miscarriage rate, clinical pregnancy rate, clinical miscarriage rate and live birth rate were compared. Results There were no significant differences in endometrial thickness before transplantation ［(group A:(0.74±0.11)mm vs(0.76±0.10)mm, P=0.422; group B:(0.73±0.11)mm vs(0.73±0.10)mm, P=0.854)］ and endometrial blood flow(group A: P=0.697; group B: P=0.835)between treatment group and control group in the age subgroups. In group A, there were no significant differences between treatment group and control group in biochemical pregnancy rate(65.5% vs 50.0%, P=0.103), clinical pregnancy rate(51.7% vs 46.0%, P=0.553)and live birth rate(37.9% vs 40.0%, P=0.826). In group B, compared with the control group, the treatment group had higher biochemical pregnancy rate(64.5% vs 38.3%, P=0.023), higher clinical pregnancy rate(61.3% vs 25.5%, P=0.002)and higher live birth rate(45.2% vs 21.3%, P=0.025)but lower biochemical miscarriage rate(5.0% vs 33.3%, P=0.038). Conclusion Intracavitary physiotherapy improves the pregnancy outcomes in women aged 35 to 42 with thin endometrium.

Key words: Intracavitary physiotherapy, Thin endometrium, Frozen-thawed embryo transfer, Pregnancy outcome

中图分类号: 

  • R715.2
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